Abstract
An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 244-248 |
| Number of pages | 5 |
| Journal | Pediatric Diabetes |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2005 |
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Keywords
- Autoantigen
- Autoimmunity
- Pediatric
- Schwann cell
ASJC Scopus subject areas
- Internal Medicine
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
Cite this
Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus. / Fudge, Elizabeth; Carroll, James Edwin; She, Jin-Xiong; Dosch, Michael; Atkinson, Mark; Muir, Andrew.
In: Pediatric Diabetes, Vol. 6, No. 4, 01.12.2005, p. 244-248.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus
AU - Fudge, Elizabeth
AU - Carroll, James Edwin
AU - She, Jin-Xiong
AU - Dosch, Michael
AU - Atkinson, Mark
AU - Muir, Andrew
PY - 2005/12/1
Y1 - 2005/12/1
N2 - An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.
AB - An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.
KW - Autoantigen
KW - Autoimmunity
KW - Pediatric
KW - Schwann cell
UR - http://www.scopus.com/inward/record.url?scp=29544437324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29544437324&partnerID=8YFLogxK
U2 - 10.1111/j.1399-543X.2005.00130.x
DO - 10.1111/j.1399-543X.2005.00130.x
M3 - Article
C2 - 16390395
AN - SCOPUS:29544437324
VL - 6
SP - 244
EP - 248
JO - Pediatric Diabetes
JF - Pediatric Diabetes
SN - 1399-543X
IS - 4
ER -