Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus

Elizabeth Fudge, James Carol, Jin Xiong She, Michael Dosch, Mark Atkinson, Andrew Muir

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalPediatric Diabetes
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2005

Keywords

  • Autoantigen
  • Autoimmunity
  • Pediatric
  • Schwann cell

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

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