Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus

Elizabeth Fudge; James Carol; Jin Xiong She; Michael Dosch; Mark Atkinson; Andrew Muir

doi:10.1111/j.1399-543X.2005.00130.x

Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus

Elizabeth Fudge, James Carol, Jin Xiong She, Michael Dosch, Mark Atkinson, Andrew Muir

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An association between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and type 1 diabetes has been described in adults, but not previously in children. Two adolescents with both CIDP and type 1 diabetes are reported here. In order to raise the awareness of CIDP among pediatricians, a description of the clinical and laboratory features, treatment, and prognosis of the condition is provided. A preliminary study was undertaken to determine whether responses to autoantigens in peri-islet Schwann cells and Schwann cells may account for the association between type 1 diabetes and CIDP. Lymphocyte proliferation in response to these autoantigens was abnormal in one of the two patients, but was also abnormal in one control subject.

Original language	English (US)
Pages (from-to)	244-248
Number of pages	5
Journal	Pediatric Diabetes
Volume	6
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-543X.2005.00130.x
State	Published - Dec 1 2005

Keywords

Autoantigen
Autoimmunity
Pediatric
Schwann cell

ASJC Scopus subject areas

Internal Medicine
Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism

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