Chronic nephrotoxicity complicating cyclosporine treatment of chronic inflammatory demyelinating polyradiculo-neuropathy

Seth Kolkin, Norris Stanley Nahman, Jerry R. Mendell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We elected to use cyclosporin A (CsA) in a woman debilitated by refractory chronic inflammatory demyelinating polyradiculoneuropathy. Although strength improved coincident with CsA therapy, after 21 months she developed congestive heart failure and had a precipitous loss of renal function with chronic renal failure requiring hemodialysis. While most CsA-induced nephrotoxicity is dose related and reversible, the kidney biopsy in our patient showed chronic nephropathy, a complication previously unreported in the native kidney of a nontransplant patient. A slow rise in blood pressure preceded serum creatinine changes and was an early indicator of impending irreversible nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalNeurology
Volume37
Issue number1
StatePublished - Jan 1 1987
Externally publishedYes

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Cyclosporine
Kidney
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Chronic Kidney Failure
Renal Dialysis
Creatinine
Therapeutics
Heart Failure
Blood Pressure
Biopsy
Serum

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Chronic nephrotoxicity complicating cyclosporine treatment of chronic inflammatory demyelinating polyradiculo-neuropathy. / Kolkin, Seth; Nahman, Norris Stanley; Mendell, Jerry R.

In: Neurology, Vol. 37, No. 1, 01.01.1987, p. 147-149.

Research output: Contribution to journalArticle

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