Chronic valproate administration reduces fasting ketonemia in children

Jean Holowach Thurston, James Edwin Carroll, W. Edwin Dodson, Richard E. Hauhart, Valann Tasch

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We previously found that chronic administration of sodium valproate to suckling infant mice reduced plasma β-hydroxybutyrate levels but had no effect on plasma free fatty acid or glycerol concentrations. We now report that valproate has a similar effect in children taking the drug for epilepsy. In larger doses, valproate also depleted the infant mouse liver glycogen content. These findings may relate to the hepatic toxicity of valproate. We advise caution if the drug is being considered for use in chronically malnourished children or when the caloric intake of normal children is likely to be reduced during periods of acute illness.

Original languageEnglish (US)
Pages (from-to)1348-1350
Number of pages3
JournalNeurology
Volume33
Issue number10
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Ketosis
Valproic Acid
Fasting
Hydroxybutyrates
Liver Glycogen
Energy Intake
Nonesterified Fatty Acids
Pharmaceutical Preparations
Glycerol
Epilepsy
Liver

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Thurston, J. H., Carroll, J. E., Dodson, W. E., Hauhart, R. E., & Tasch, V. (1983). Chronic valproate administration reduces fasting ketonemia in children. Neurology, 33(10), 1348-1350.

Chronic valproate administration reduces fasting ketonemia in children. / Thurston, Jean Holowach; Carroll, James Edwin; Dodson, W. Edwin; Hauhart, Richard E.; Tasch, Valann.

In: Neurology, Vol. 33, No. 10, 01.01.1983, p. 1348-1350.

Research output: Contribution to journalArticle

Thurston, JH, Carroll, JE, Dodson, WE, Hauhart, RE & Tasch, V 1983, 'Chronic valproate administration reduces fasting ketonemia in children', Neurology, vol. 33, no. 10, pp. 1348-1350.
Thurston JH, Carroll JE, Dodson WE, Hauhart RE, Tasch V. Chronic valproate administration reduces fasting ketonemia in children. Neurology. 1983 Jan 1;33(10):1348-1350.
Thurston, Jean Holowach ; Carroll, James Edwin ; Dodson, W. Edwin ; Hauhart, Richard E. ; Tasch, Valann. / Chronic valproate administration reduces fasting ketonemia in children. In: Neurology. 1983 ; Vol. 33, No. 10. pp. 1348-1350.
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