Circadian disrupting exposures and breast cancer risk

a meta-analysis

Chunla He, Sonia Taj Anand, Mark H. Ebell, John E. Vena, Sara Wagner Robb

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Purpose: Shift work, short sleep duration, employment as a flight attendant, and exposure to light at night, all potential causes of circadian disruption, have been inconsistently associated with breast cancer (BrCA) risk. The aim of this meta-analysis is to quantitatively evaluate the combined and independent effects of exposure to different sources of circadian disruption on BrCA risk in women. Methods: Relevant studies published through January 2014 were identified by searching the PubMed database. The pooled relative risks (RRs) and corresponding 95 % confidence intervals (CIs) were estimated using fixed- or random effects models as indicated by heterogeneity tests. Generalized least squares trend test was used to assess dose–response relationships. Results: A total of 28 studies, 15 on shift work, 7 on short sleep duration, 3 on flight attendants, and 6 on light at night were included in the analysis. The combined analysis suggested a significantly positive association between circadian disruption and BrCA risk (RR = 1.14; 95 % CI 1.08–1.21). Separate analyses showed that the RR for BrCA was 1.19 (95 % CI 1.08–1.32) for shift work, 1.120 (95 % CI 1.119–1.121) for exposure to light at night, 1.56 (95 % CI 1.10–2.21) for employment as a flight attendant, and 0.96 (95 % CI 0.86–1.06) for short sleep duration. A dose–response analysis showed that each 10-year increment of shift work was associated with 16 % higher risk of BrCA (95 % CI 1.06–1.27) based on selected case–control studies. No significant dose–response effects of exposure to light at night and sleep deficiency were found on BrCA risk. Conclusions: Our meta-analysis demonstrates that circadian disruption is associated with an increased BrCA risk in women. This association varied by specific sources of circadian disrupting exposures, and a dose–response relationship remains uncertain. Therefore, future rigorous prospective studies are needed to confirm these relationships.

Original languageEnglish (US)
Pages (from-to)533-547
Number of pages15
JournalInternational Archives of Occupational and Environmental Health
Volume88
Issue number5
DOIs
StatePublished - Jul 18 2015

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Meta-Analysis
Breast Neoplasms
Confidence Intervals
Sleep
Light
Least-Squares Analysis
PubMed
Databases
Prospective Studies

Keywords

  • Breast cancer
  • Circadian disruption
  • Meta-analysis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Circadian disrupting exposures and breast cancer risk : a meta-analysis. / He, Chunla; Anand, Sonia Taj; Ebell, Mark H.; Vena, John E.; Robb, Sara Wagner.

In: International Archives of Occupational and Environmental Health, Vol. 88, No. 5, 18.07.2015, p. 533-547.

Research output: Contribution to journalArticle

He, Chunla ; Anand, Sonia Taj ; Ebell, Mark H. ; Vena, John E. ; Robb, Sara Wagner. / Circadian disrupting exposures and breast cancer risk : a meta-analysis. In: International Archives of Occupational and Environmental Health. 2015 ; Vol. 88, No. 5. pp. 533-547.
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abstract = "Purpose: Shift work, short sleep duration, employment as a flight attendant, and exposure to light at night, all potential causes of circadian disruption, have been inconsistently associated with breast cancer (BrCA) risk. The aim of this meta-analysis is to quantitatively evaluate the combined and independent effects of exposure to different sources of circadian disruption on BrCA risk in women. Methods: Relevant studies published through January 2014 were identified by searching the PubMed database. The pooled relative risks (RRs) and corresponding 95 {\%} confidence intervals (CIs) were estimated using fixed- or random effects models as indicated by heterogeneity tests. Generalized least squares trend test was used to assess dose–response relationships. Results: A total of 28 studies, 15 on shift work, 7 on short sleep duration, 3 on flight attendants, and 6 on light at night were included in the analysis. The combined analysis suggested a significantly positive association between circadian disruption and BrCA risk (RR = 1.14; 95 {\%} CI 1.08–1.21). Separate analyses showed that the RR for BrCA was 1.19 (95 {\%} CI 1.08–1.32) for shift work, 1.120 (95 {\%} CI 1.119–1.121) for exposure to light at night, 1.56 (95 {\%} CI 1.10–2.21) for employment as a flight attendant, and 0.96 (95 {\%} CI 0.86–1.06) for short sleep duration. A dose–response analysis showed that each 10-year increment of shift work was associated with 16 {\%} higher risk of BrCA (95 {\%} CI 1.06–1.27) based on selected case–control studies. No significant dose–response effects of exposure to light at night and sleep deficiency were found on BrCA risk. Conclusions: Our meta-analysis demonstrates that circadian disruption is associated with an increased BrCA risk in women. This association varied by specific sources of circadian disrupting exposures, and a dose–response relationship remains uncertain. Therefore, future rigorous prospective studies are needed to confirm these relationships.",
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