Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans

J. G. Cannon, J. S. Friedberg, J. A. Gelfand, R. G. Tompkins, J. F. Burke, C. A. Dinarello

Research output: Contribution to journalArticle

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Abstract

Objectives: To measure plasma interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα) concentrations after burn injury and to determine if these concentrations relate to clinical status. Design: Prospective assessment. Setting: Hospital burn unit. Patients: Thirty-one patients with second- or third-degree burns, covering 10% to 95% of body surface area. Measurements and Main Results: Initial concentrations of IL-1β were increased (mean 188 ± 31 pg/mL), and the concentrations for each patient correlated with body temperature at the time of the blood sample (rho = 0.51, p < .015) (rho is a nonparametric statistical measure; a non-parametric analysis is mandatory for data that is categorical [Acute Physiology and Chronic Health Evaluation, APACHE, scores] and data that are not normally distributed [IL-1β and tumor necrosis factor, TNF, data]). Mean TNFα concentrations were initially 264 ± 132 pg/mL, and these concentrations were positively related to body temperature (rho = 0.41, p < .05) and inversely related to the total WBC count (rho = -0.45, p < .025). Through the course of hospitalization, plasma cytokine levels fluctuated, but transient increases (sometimes into the nanogram/mL range) did not consistently correspond to changes in clinical signs or severity of illness, as determined by APACHE II scores. The maximum plasma cytokine levels in any patient were not related to age, but maximum IL-1β concentrations were inversely related to burn size (rho = -0.46, p < .015). The final IL-1β concentrations measured in the patients who died (n = 7) were significantly less than measurements in surviving patients matched for burn size and age taken at approximately the same time after admission. Conclusions: These results indicate that early after burn injury there is a correspondence of IL-1β and TNFα with certain host responses, but these correlations disappear with the progression of illness. In general, IL-1β and TNFα appear to be poor indicators of prognosis during burn injury; however, the association of mortality with low circulating IL-1β values supports the concept of IL-1β as being an essential mediator of host defenses.

Original languageEnglish (US)
Pages (from-to)1414-1419
Number of pages6
JournalCritical Care Medicine
Volume20
Issue number10
DOIs
StatePublished - Jan 1 1992

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Interleukin-1
Tumor Necrosis Factor-alpha
Wounds and Injuries
APACHE
Body Temperature
Cytokines
Burn Units
Hospital Units
Body Surface Area
Burns
Hospitalization
Mortality

Keywords

  • age
  • APACHE II score
  • body temperature
  • burn
  • critical illness
  • cytokine
  • fever
  • interleukin-1
  • neutrophil
  • sepsis
  • trauma
  • tumor necrosis factor

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Cannon, J. G., Friedberg, J. S., Gelfand, J. A., Tompkins, R. G., Burke, J. F., & Dinarello, C. A. (1992). Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans. Critical Care Medicine, 20(10), 1414-1419. https://doi.org/10.1097/00003246-199210000-00009

Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans. / Cannon, J. G.; Friedberg, J. S.; Gelfand, J. A.; Tompkins, R. G.; Burke, J. F.; Dinarello, C. A.

In: Critical Care Medicine, Vol. 20, No. 10, 01.01.1992, p. 1414-1419.

Research output: Contribution to journalArticle

Cannon, JG, Friedberg, JS, Gelfand, JA, Tompkins, RG, Burke, JF & Dinarello, CA 1992, 'Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans', Critical Care Medicine, vol. 20, no. 10, pp. 1414-1419. https://doi.org/10.1097/00003246-199210000-00009
Cannon, J. G. ; Friedberg, J. S. ; Gelfand, J. A. ; Tompkins, R. G. ; Burke, J. F. ; Dinarello, C. A. / Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans. In: Critical Care Medicine. 1992 ; Vol. 20, No. 10. pp. 1414-1419.
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abstract = "Objectives: To measure plasma interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα) concentrations after burn injury and to determine if these concentrations relate to clinical status. Design: Prospective assessment. Setting: Hospital burn unit. Patients: Thirty-one patients with second- or third-degree burns, covering 10{\%} to 95{\%} of body surface area. Measurements and Main Results: Initial concentrations of IL-1β were increased (mean 188 ± 31 pg/mL), and the concentrations for each patient correlated with body temperature at the time of the blood sample (rho = 0.51, p < .015) (rho is a nonparametric statistical measure; a non-parametric analysis is mandatory for data that is categorical [Acute Physiology and Chronic Health Evaluation, APACHE, scores] and data that are not normally distributed [IL-1β and tumor necrosis factor, TNF, data]). Mean TNFα concentrations were initially 264 ± 132 pg/mL, and these concentrations were positively related to body temperature (rho = 0.41, p < .05) and inversely related to the total WBC count (rho = -0.45, p < .025). Through the course of hospitalization, plasma cytokine levels fluctuated, but transient increases (sometimes into the nanogram/mL range) did not consistently correspond to changes in clinical signs or severity of illness, as determined by APACHE II scores. The maximum plasma cytokine levels in any patient were not related to age, but maximum IL-1β concentrations were inversely related to burn size (rho = -0.46, p < .015). The final IL-1β concentrations measured in the patients who died (n = 7) were significantly less than measurements in surviving patients matched for burn size and age taken at approximately the same time after admission. Conclusions: These results indicate that early after burn injury there is a correspondence of IL-1β and TNFα with certain host responses, but these correlations disappear with the progression of illness. In general, IL-1β and TNFα appear to be poor indicators of prognosis during burn injury; however, the association of mortality with low circulating IL-1β values supports the concept of IL-1β as being an essential mediator of host defenses.",
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AU - Tompkins, R. G.

AU - Burke, J. F.

AU - Dinarello, C. A.

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N2 - Objectives: To measure plasma interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα) concentrations after burn injury and to determine if these concentrations relate to clinical status. Design: Prospective assessment. Setting: Hospital burn unit. Patients: Thirty-one patients with second- or third-degree burns, covering 10% to 95% of body surface area. Measurements and Main Results: Initial concentrations of IL-1β were increased (mean 188 ± 31 pg/mL), and the concentrations for each patient correlated with body temperature at the time of the blood sample (rho = 0.51, p < .015) (rho is a nonparametric statistical measure; a non-parametric analysis is mandatory for data that is categorical [Acute Physiology and Chronic Health Evaluation, APACHE, scores] and data that are not normally distributed [IL-1β and tumor necrosis factor, TNF, data]). Mean TNFα concentrations were initially 264 ± 132 pg/mL, and these concentrations were positively related to body temperature (rho = 0.41, p < .05) and inversely related to the total WBC count (rho = -0.45, p < .025). Through the course of hospitalization, plasma cytokine levels fluctuated, but transient increases (sometimes into the nanogram/mL range) did not consistently correspond to changes in clinical signs or severity of illness, as determined by APACHE II scores. The maximum plasma cytokine levels in any patient were not related to age, but maximum IL-1β concentrations were inversely related to burn size (rho = -0.46, p < .015). The final IL-1β concentrations measured in the patients who died (n = 7) were significantly less than measurements in surviving patients matched for burn size and age taken at approximately the same time after admission. Conclusions: These results indicate that early after burn injury there is a correspondence of IL-1β and TNFα with certain host responses, but these correlations disappear with the progression of illness. In general, IL-1β and TNFα appear to be poor indicators of prognosis during burn injury; however, the association of mortality with low circulating IL-1β values supports the concept of IL-1β as being an essential mediator of host defenses.

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KW - critical illness

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KW - fever

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KW - trauma

KW - tumor necrosis factor

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