Circulating levels of inflammatory cytokines and risk of colorectal adenomas

Sangmi Kim, Temitope O. Keku, Christopher Martin, Joseph Galanko, John T. Woosley, Jane C. Schroeder, Jessie A. Satia, Susan Halabi, Robert S. Sandler

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Abstract

The association between obesity and colorectal neoplasia may be mediated by inflammation. Circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) are elevated in the obese. Adipose tissue can produce and release the inflammatory cytokines that are potentially procarcinogenic. We examined circulating levels of CRP, IL-6, and TNF-α in relation to risk factors and the prevalence of colorectal adenomas. Plasma levels of CRP, IL-6, and TNF-α were quantified in 873 participants (242 colorectal adenoma cases and 631 controls) in a colonoscopy-based cross-sectional study conducted between 1998 and 2002. Multivariable logistic regression was used to estimate associations between known risk factors for colorectal neoplasia and circulating levels of inflammatory cytokines and associations between inflammatory cytokines and colorectal adenomas. Several known risk factors for colorectal neoplasia were associated with higher levels of inflammatory cytokines, including older age, current smoking, and increasing adiposity. The prevalence of colorectal adenomas was associated with higher concentrations of IL-6 and TNF-α and, to a lesser degree, with CRP. For IL-6, adjusted odds ratios (OR) for colorectal adenomas were 1.79 [95% confidence interval (CI), 1.19-2.69] for the second highest plasma level and 1.85 (95% CI, 1.24-2.75) for the highest level compared with the reference level. A similar association was found with TNF-α, with adjusted ORs of 1.56 (95% CI, 1.03-2.36) and 1.66 (95% CI, 1.10-2.52), respectively. Our findings indicate that systemic inflammation might be involved in the early development of colorectal neoplasia.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalCancer Research
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2008

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Adenoma
Interleukin-6
Tumor Necrosis Factor-alpha
C-Reactive Protein
Cytokines
Confidence Intervals
Neoplasms
Inflammation
Adiposity
Colonoscopy
Adipose Tissue
Obesity
Cross-Sectional Studies
Logistic Models
Smoking
Odds Ratio

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kim, S., Keku, T. O., Martin, C., Galanko, J., Woosley, J. T., Schroeder, J. C., ... Sandler, R. S. (2008). Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Research, 68(1), 323-328. https://doi.org/10.1158/0008-5472.CAN-07-2924

Circulating levels of inflammatory cytokines and risk of colorectal adenomas. / Kim, Sangmi; Keku, Temitope O.; Martin, Christopher; Galanko, Joseph; Woosley, John T.; Schroeder, Jane C.; Satia, Jessie A.; Halabi, Susan; Sandler, Robert S.

In: Cancer Research, Vol. 68, No. 1, 01.01.2008, p. 323-328.

Research output: Contribution to journalArticle

Kim, S, Keku, TO, Martin, C, Galanko, J, Woosley, JT, Schroeder, JC, Satia, JA, Halabi, S & Sandler, RS 2008, 'Circulating levels of inflammatory cytokines and risk of colorectal adenomas', Cancer Research, vol. 68, no. 1, pp. 323-328. https://doi.org/10.1158/0008-5472.CAN-07-2924
Kim S, Keku TO, Martin C, Galanko J, Woosley JT, Schroeder JC et al. Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Research. 2008 Jan 1;68(1):323-328. https://doi.org/10.1158/0008-5472.CAN-07-2924
Kim, Sangmi ; Keku, Temitope O. ; Martin, Christopher ; Galanko, Joseph ; Woosley, John T. ; Schroeder, Jane C. ; Satia, Jessie A. ; Halabi, Susan ; Sandler, Robert S. / Circulating levels of inflammatory cytokines and risk of colorectal adenomas. In: Cancer Research. 2008 ; Vol. 68, No. 1. pp. 323-328.
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