Circulating proangiogenic cell activity is associated with cardiovascular disease risk

Kreton Mavromatis, Konstantinos Aznaouridis, Ibhar Al Mheid, Emir Veledar, Saurabh Dhawan, Jonathan R. Murrow, Zohreh Forghani, Diane J. Sutcliffe, Nima Ghasemzadeh, R. Wayne Alexander, W. Robert Taylor, Arshed A. Quyyumi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Vascular injury mobilizes bone marrow-derived proangiogenic cells into the circulation, where these cells can facilitate vascular repair and new vessel formation. We sought to determine the relationship between a new biomarker of circulating bone marrow-derived proangiogenic cell activity, the presence of atherosclerotic cardiovascular disease (CVD) and its risk factors, and clinical outcomes. Circulating proangiogenic cell activity was estimated using a reproducible angiogenic colony-forming unit (CFU-A) assay in 532 clinically stable subjects aged 20 to 90 years and ranging in the CVD risk spectrum from those who are healthy without risk factors to those with active CVD. CFU-A counts increased with the burden of CVD risk factors (p < 0.001). CFU-A counts were higher in subjects with symptomatic CVD than in those without (p < 0.001). During follow-up of 232 subjects with CVD, CFU-A counts were higher in those with death, myocardial infarction, or stroke than in those without (110 [70-173] vs 84 [51-136], p = 0.01). Therefore, we conclude that circulating proangiogenic cell activity, as estimated by CFU-A counts, increases with CVD risk factor burden and in the presence of established CVD. Furthermore, higher circulating proangiogenic cell activity is associated with worse clinical outcome in those with CVD.

Original languageEnglish (US)
Pages (from-to)1163-1170
Number of pages8
JournalJournal of Biomolecular Screening
Volume17
Issue number9
DOIs
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • biomarkers
  • cardiac diseases
  • cell-based assay
  • stem cells

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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  • Cite this

    Mavromatis, K., Aznaouridis, K., Al Mheid, I., Veledar, E., Dhawan, S., Murrow, J. R., Forghani, Z., Sutcliffe, D. J., Ghasemzadeh, N., Wayne Alexander, R., Robert Taylor, W., & Quyyumi, A. A. (2012). Circulating proangiogenic cell activity is associated with cardiovascular disease risk. Journal of Biomolecular Screening, 17(9), 1163-1170. https://doi.org/10.1177/1087057112454919