Circulating soluble E-selectin levels and the Ser128Arg polymorphism in individuals from different ethnic groups

Michelle A. Miller, Sally M. Kerry, Yanbin Dong, Giuseppe A. Sagnella, Derek G. Cook, Francesco P. Cappuccio

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background and aim: An association between the Ser128Arg polymorphism and coronary heart disease (CHD) has been previously demonstrated in a white population. The aim of this study was to investigate whether the Ser128Arg polymorphism of the E-selectin gene is associated with soluble E-selectin levels in individuals from a multiethnic population. Methods and results: Plasma sE-selectin levels and the Ser128Arg E-selectin gene polymorphism were determined in 244 white (109 females), 176 of African origin (90 females) and 208 South Asian (95 females) healthy individuals living in England selected from the Wandsworth Heart and Stroke Study (WHSS). The substitution of serine for arginine (A to C mutation) was more common in whites (9.6%) and South Asians (7.9%) compared to the people of African origin (3.7%); p = 0.005. The C mutation had no effect on sE-selectin levels in any ethnic group. Conclusions: We found a lower frequency of this polymorphism in the people of African origin who have a low CHD risk. However, in this study the polymorphism was not associated with circulating sE-selectin levels. Whether it plays a role in determining ethnic differences in vascular disease via a mechanism affecting leukocyte recruitment remains to be determined.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2005

Fingerprint

Selectins
E-Selectin
Ethnic Groups
Coronary Disease
Mutation
Vascular Diseases
England
Serine
Population
Genes
Arginine
Leukocytes
Stroke

Keywords

  • Cardiovascular disease
  • Cell adhesion molecules
  • Ethnicity
  • Polymorphism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Circulating soluble E-selectin levels and the Ser128Arg polymorphism in individuals from different ethnic groups. / Miller, Michelle A.; Kerry, Sally M.; Dong, Yanbin; Sagnella, Giuseppe A.; Cook, Derek G.; Cappuccio, Francesco P.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 15, No. 1, 01.01.2005, p. 65-70.

Research output: Contribution to journalArticle

Miller, Michelle A. ; Kerry, Sally M. ; Dong, Yanbin ; Sagnella, Giuseppe A. ; Cook, Derek G. ; Cappuccio, Francesco P. / Circulating soluble E-selectin levels and the Ser128Arg polymorphism in individuals from different ethnic groups. In: Nutrition, Metabolism and Cardiovascular Diseases. 2005 ; Vol. 15, No. 1. pp. 65-70.
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abstract = "Background and aim: An association between the Ser128Arg polymorphism and coronary heart disease (CHD) has been previously demonstrated in a white population. The aim of this study was to investigate whether the Ser128Arg polymorphism of the E-selectin gene is associated with soluble E-selectin levels in individuals from a multiethnic population. Methods and results: Plasma sE-selectin levels and the Ser128Arg E-selectin gene polymorphism were determined in 244 white (109 females), 176 of African origin (90 females) and 208 South Asian (95 females) healthy individuals living in England selected from the Wandsworth Heart and Stroke Study (WHSS). The substitution of serine for arginine (A to C mutation) was more common in whites (9.6{\%}) and South Asians (7.9{\%}) compared to the people of African origin (3.7{\%}); p = 0.005. The C mutation had no effect on sE-selectin levels in any ethnic group. Conclusions: We found a lower frequency of this polymorphism in the people of African origin who have a low CHD risk. However, in this study the polymorphism was not associated with circulating sE-selectin levels. Whether it plays a role in determining ethnic differences in vascular disease via a mechanism affecting leukocyte recruitment remains to be determined.",
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