TY - JOUR
T1 - Classifying distinct basal cell carcinoma subtype by means of dermatoscopy and reflectance confocal microscopy
AU - Longo, Caterina
AU - Lallas, Aimilios
AU - Kyrgidis, Athanassios
AU - Rabinovitz, Harold
AU - Moscarella, Elvira
AU - Ciardo, Silvana
AU - Zalaudek, Iris
AU - Oliviero, Margaret
AU - Losi, Amanda
AU - Gonzalez, Salvador
AU - Guitera, Pascale
AU - Piana, Simonetta
AU - Argenziano, Giuseppe
AU - Pellacani, Giovanni
N1 - Funding Information:
Supported in part by the Italian Ministry of Health ( RF-2010-2316524 ).
PY - 2014
Y1 - 2014
N2 - Background: The current guidelines for the management of basal cell carcinoma (BCC) suggest a different therapeutic approach according to histopathologic subtype. Although dermatoscopic and confocal criteria of BCC have been investigated, no specific studies were performed to evaluate the distinct reflectance confocal microscopy (RCM) aspects of BCC subtypes. Objectives: To define the specific dermatoscopic and confocal criteria for delineating differentBCCsubtypes. Methods: Dermatoscopic and confocal images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Frequencies of dermatoscopic and confocal parameters are provided. Univariate and adjusted odds ratios were calculated. Discriminant analyses were performed to define the independent confocal criteria for distinct BCC subtypes. Results: Eighty-eight BCCs were included. Dermatoscopically, superficial BCCs (n = 44) were primarily typified by the presence of fine telangiectasia, multiple erosions, leaf-like structures, and revealed cords connected to the epidermis and epidermal streaming upon RCM. Nodular BCCs (n = 22) featured the classic dermatoscopic features and well outlined large basaloid islands upon RCM. Infiltrative BCCs (n = 22) featured structureless, shiny red areas, fine telangiectasia, and arborizing vessels on dermatoscopy and dark silhouettes upon RCM. Limitations: The retrospective design. Conclusion: Dermatoscopy and confocal microscopy can reliably classify different BCC subtypes. ( JAmAcad Dermatol 2014;71:716-24.).
AB - Background: The current guidelines for the management of basal cell carcinoma (BCC) suggest a different therapeutic approach according to histopathologic subtype. Although dermatoscopic and confocal criteria of BCC have been investigated, no specific studies were performed to evaluate the distinct reflectance confocal microscopy (RCM) aspects of BCC subtypes. Objectives: To define the specific dermatoscopic and confocal criteria for delineating differentBCCsubtypes. Methods: Dermatoscopic and confocal images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Frequencies of dermatoscopic and confocal parameters are provided. Univariate and adjusted odds ratios were calculated. Discriminant analyses were performed to define the independent confocal criteria for distinct BCC subtypes. Results: Eighty-eight BCCs were included. Dermatoscopically, superficial BCCs (n = 44) were primarily typified by the presence of fine telangiectasia, multiple erosions, leaf-like structures, and revealed cords connected to the epidermis and epidermal streaming upon RCM. Nodular BCCs (n = 22) featured the classic dermatoscopic features and well outlined large basaloid islands upon RCM. Infiltrative BCCs (n = 22) featured structureless, shiny red areas, fine telangiectasia, and arborizing vessels on dermatoscopy and dark silhouettes upon RCM. Limitations: The retrospective design. Conclusion: Dermatoscopy and confocal microscopy can reliably classify different BCC subtypes. ( JAmAcad Dermatol 2014;71:716-24.).
KW - Basal cell carcinoma
KW - Dermatoscopy
KW - Dermoscopy
KW - Diagnosis
KW - Infiltrative basal cell carcinoma
KW - Nodular basal cell carcinoma
KW - Reflectance confocal microscopy
KW - Superficial basal cell carcinoma.
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U2 - 10.1016/j.jaad.2014.04.067
DO - 10.1016/j.jaad.2014.04.067
M3 - Article
C2 - 24928707
AN - SCOPUS:84910156812
SN - 0190-9622
VL - 71
SP - 716-724.e1
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -