Clear cell adenocarcinoma of the lung: A SEER analysis

Takefumi Komiya, Achuta Kumar Guddati, Yukihiro Nakanishi

Research output: Contribution to journalArticle

Abstract

Clear cell adenocarcinoma (CCA) in lung has been considered as a rare subtype of lung adenocarcinoma. However, recent classifications of lung adenocarcinoma proposed to discontinue CCA due to lack of available data with clinical significance. Patients with CCA and lung adenocarcinoma not otherwise specified (LANOS) were queried from The Surveillance, Epidemiology, and End Results Program (SEER) database. Cancer-specific survival was studied according to gender (male, female), age (0–69, 70+), SEER specific stage A system (localized, regional and distant), year of diagnosis (1973–2000, 2001–2013), surgery (yes, no), and radiation therapy (yes, no) using Kaplan-Meier curves. Multivariate analysis was used to study independent predictors of cancer-specific survival. A total of 1,227 and 233,154 patients with the diagnosis of CCA and LANOS respectively were found in the SEER database. CCA histology was significantly associated with an early year of diagnosis, younger age, early stage, surgery, and lack of radiation. Kaplan-Meier curves showed that patients with CCA histology had significantly better cancer-specific survival (P<0.0001, Log-Rank). Subset analysis demonstrated the difference in cancer-specific survival between CCA and NOS histology was significant in localized and regional but not distant stage disease (P=0.0453, 0.0009, 0.0664, respectively). Patients with CCA histology have superior survival in the locoregional stage according to our SEER analysis, suggesting its unique role in prognosis despite it being removed from recent pathologic classifications.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalTranslational Lung Cancer Research
Volume8
Issue number2
DOIs
StatePublished - Apr 1 2019

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Clear Cell Adenocarcinoma
SEER Program
Histology
Survival
Neoplasms
Databases
Adenocarcinoma of lung
Early Diagnosis
Radiotherapy
Multivariate Analysis
Radiation

Keywords

  • Cancer-specific survival
  • Clear cell adenocarcinoma (CCA)
  • Non-small cell lung cancer (NSCLC)
  • Surveillance, Epidemiology, and End Results (SEER)

ASJC Scopus subject areas

  • Oncology

Cite this

Clear cell adenocarcinoma of the lung : A SEER analysis. / Komiya, Takefumi; Guddati, Achuta Kumar; Nakanishi, Yukihiro.

In: Translational Lung Cancer Research, Vol. 8, No. 2, 01.04.2019, p. 187-191.

Research output: Contribution to journalArticle

Komiya, Takefumi ; Guddati, Achuta Kumar ; Nakanishi, Yukihiro. / Clear cell adenocarcinoma of the lung : A SEER analysis. In: Translational Lung Cancer Research. 2019 ; Vol. 8, No. 2. pp. 187-191.
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