Clerodendron glandulosum Coleb methanolic extract ameliorates high fat diet induced hyper lipidemia in male rats

D. K. Patel, R. K. Bhatt, S. N. Desai, M. C. Thounaojam, R. N. Jadeja, Ansarullah, S. P. Salunke, G. S. Padate, R. V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

Abstract

In recent times, herbal drugs with lipid lowering potential have received considerable attention because these drugs have relatively less side effect unlike synthetic drugs. This study assesses the lipid lowering property of Clerodendron glandulosum Coleb. (CG) methanolic extract in experimentally induced hyperlipidemia by feeding rats with hyperlipidemic diet (HL). It was observed that CG extract restored the plasma lipid profile of HL rats to levels comparable to control, with increase in high density lipoproteins being the most significant finding. CG restored the high fat diet induced alterations in liver and renal functions as was evident from the activity levels of relevant enzymes. Elevated levels of lipids and triglycerides eliminated through faeces, further substantiate the role of CG as a potent lipid lowering agent. Results envisaged herein, indicates the ability of CG extract as a potent lipid lowering agent in experimentally induced hyperlipidemia.

Original languageEnglish (US)
Pages (from-to)323-331
Number of pages9
JournalPharmacologyonline
Volume2
StatePublished - Sep 17 2009

Keywords

  • Clerodendron glandulosum coleb
  • Hypercholestremia
  • Hyperlipidemia

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Patel, D. K., Bhatt, R. K., Desai, S. N., Thounaojam, M. C., Jadeja, R. N., Ansarullah, Salunke, S. P., Padate, G. S., Devkar, R. V., & Ramachandran, A. V. (2009). Clerodendron glandulosum Coleb methanolic extract ameliorates high fat diet induced hyper lipidemia in male rats. Pharmacologyonline, 2, 323-331.