Clerodendron glandulosum Coleb., Verbenaceae, melhora a dieta rica em gordura induzida por alteração no metabolismo de lipídios e colesterol em ratos

Translated title of the contribution: Clerodendron glandulosum Coleb., Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats

R. N. Jadeja, M. C. Thounaojam, Ansarullah, R. V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The present study was undertaken to evaluate the efficacy of freeze dried extract of Clerodendron glandulosum Coleb., Verbenaceae, leaves (FECG) on alteration in lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FECG treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug Lovastatin (LVS). Results indicate that FECG was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in C. glandulosum. Use of C. glandulosum extract as a potential therapeutic agent against hypercholesterolemia and hypertriglyceridemia is indicated.

Original languagePortuguese
Pages (from-to)117-123
Number of pages7
JournalBrazilian Journal of Pharmacognosy
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

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Keywords

  • Clerodendron glandulosum
  • Hypercholesterolemia
  • Hyperlipidemia
  • Verbenaceae

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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