Clindamycin-associated hepatotoxicity

Michael Elmore, John Peter Rissing, Lawrence Rink, Geo F. Brooks

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Hepatotoxicity associated with intravenous clindamycin phosphate therapy is reported in a drug abuser cured of staphylococcal endocarditis. Coincident with the administration of large doses of clindamycin, marked hepatic enzyme abnormalities were noted, and liver biopsy showed lobular disruption, pseudogranulomas, hepatocyte necrosis, eosinophilic bodies and mononuclear cell infiltration. Cessation of clindamycin therapy resulted in return of liver enzymes to normal, and a second liver biopsy performed 15 days later showed improvement. Reports of clindamycin-associated hepatic enzyme changes are reviewed; further observation for clindamycin-associated hepatotoxicity is warranted.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalThe American Journal of Medicine
Volume57
Issue number4
DOIs
StatePublished - Jan 1 1974

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Clindamycin
Liver
Enzymes
Biopsy
Drug Users
Endocarditis
Hepatocytes
Necrosis
Observation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clindamycin-associated hepatotoxicity. / Elmore, Michael; Rissing, John Peter; Rink, Lawrence; Brooks, Geo F.

In: The American Journal of Medicine, Vol. 57, No. 4, 01.01.1974, p. 627-630.

Research output: Contribution to journalArticle

Elmore, Michael ; Rissing, John Peter ; Rink, Lawrence ; Brooks, Geo F. / Clindamycin-associated hepatotoxicity. In: The American Journal of Medicine. 1974 ; Vol. 57, No. 4. pp. 627-630.
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