Clinical and electroencephalographic characteristics of a metabolic encephalopathy associated with cefepime, a fourth-generation cephalosporin

Marino Muxfeldt Bianchin, Henry Mór Pansard, Carlos Alberto Michet Da Silva, Ricardo Guarnieri, Almira Vazdarjanova, Roger Walz

Research output: Contribution to journalArticle


The present report is a case study of a male patient with anuric end-stage renal failure who developed metabolic encephalopathy associated with cefepime use. This case study suggests that the role of cefepime in producing methabolic encephalopathy may be underestimated. Thus, administering cefepime to severely ill patients, or those with impaired renal function should be done very judiciously, recognizing the encephalopathic potential of cefepime.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalJournal of Epilepsy and Clinical Neurophysiology
Issue number2
Publication statusPublished - Jan 1 2004
Externally publishedYes



  • Benzodiazepines
  • Beta-lactam structure
  • Gamma-aminobutyric acid (GABA)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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