Clinical and epidemiological factors associated with suicide in colorectal cancer

Thuy T. Pham, Asif M. Talukder, Nathaniel J. Walsh, Andrew G. Lawson, Andrew J. Jones, Jessica L. Bishop, Edward James Kruse

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: While increased suicidal tendencies among cancer patients have been well documented, this study aims to examine suicide rates and factors associated with suicide specifically in patients with colorectal cancer (CRC). Methods: Patients diagnosed with CRC between the years of 1988–2010 were selected from the Surveillance, Epidemiology, and End Result (SEER) database. Comparisons with the general population were done using the National Center for Disease Control registry. Results: One thousand three hundred eighty-one suicides among 884,529 patients were identified, with a standardized mortality ratio (SMR) of 1.53 (95% CI, 1.13–1.33) compared to the general population. No statistically significant difference in suicide rate was found with respect to age, marital status, socio-economic status, surgical intervention, histologic subtype, or stage at diagnosis. Within the CRC population, Whites were significantly more likely to commit suicide than non-Whites (OR, 2.28; 95% CI, 1.89–2.75; P < 0.001), and males were significantly more likely than females (OR, 5.635; 95% CI, 4.85–6.54; P < 0.001). Most suicides occurred in patients with distal lesions in the sigmoid/rectosigmoid junction (P < 0.001). SMRs for CRC patients were 4.24 for females (95% CI, 3.69–4.86), 1.35 for males (95% CI, 1.28–1.43), 0.38 for African-Americans (95% CI, 0.28–0.52), 1.77 for Whites (95% CI, 1.68–1.87), and 0.90 for other races (95% CI, 0.72–1.12). Conclusion: Identification of risk factors associated with suicide among patients with CRC is an important step in developing screening strategies and management of psychosocial stressors. These results could be helpful in formulating a comprehensive suicide risk scoring system for screening all cancer patients.

Original languageEnglish (US)
Pages (from-to)617-621
Number of pages5
JournalSupportive Care in Cancer
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Suicide
Colorectal Neoplasms
Population
Marital Status
Sigmoid Colon
Centers for Disease Control and Prevention (U.S.)
Early Detection of Cancer
African Americans
Registries
Epidemiology
Economics
Databases
Mortality
Neoplasms

Keywords

  • Colon cancer
  • Colorectal cancer
  • Rectal cancer
  • SEER database
  • Suicide risk

ASJC Scopus subject areas

  • Oncology

Cite this

Pham, T. T., Talukder, A. M., Walsh, N. J., Lawson, A. G., Jones, A. J., Bishop, J. L., & Kruse, E. J. (2019). Clinical and epidemiological factors associated with suicide in colorectal cancer. Supportive Care in Cancer, 27(2), 617-621. https://doi.org/10.1007/s00520-018-4354-3

Clinical and epidemiological factors associated with suicide in colorectal cancer. / Pham, Thuy T.; Talukder, Asif M.; Walsh, Nathaniel J.; Lawson, Andrew G.; Jones, Andrew J.; Bishop, Jessica L.; Kruse, Edward James.

In: Supportive Care in Cancer, Vol. 27, No. 2, 01.02.2019, p. 617-621.

Research output: Contribution to journalArticle

Pham, TT, Talukder, AM, Walsh, NJ, Lawson, AG, Jones, AJ, Bishop, JL & Kruse, EJ 2019, 'Clinical and epidemiological factors associated with suicide in colorectal cancer', Supportive Care in Cancer, vol. 27, no. 2, pp. 617-621. https://doi.org/10.1007/s00520-018-4354-3
Pham TT, Talukder AM, Walsh NJ, Lawson AG, Jones AJ, Bishop JL et al. Clinical and epidemiological factors associated with suicide in colorectal cancer. Supportive Care in Cancer. 2019 Feb 1;27(2):617-621. https://doi.org/10.1007/s00520-018-4354-3
Pham, Thuy T. ; Talukder, Asif M. ; Walsh, Nathaniel J. ; Lawson, Andrew G. ; Jones, Andrew J. ; Bishop, Jessica L. ; Kruse, Edward James. / Clinical and epidemiological factors associated with suicide in colorectal cancer. In: Supportive Care in Cancer. 2019 ; Vol. 27, No. 2. pp. 617-621.
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abstract = "Purpose: While increased suicidal tendencies among cancer patients have been well documented, this study aims to examine suicide rates and factors associated with suicide specifically in patients with colorectal cancer (CRC). Methods: Patients diagnosed with CRC between the years of 1988–2010 were selected from the Surveillance, Epidemiology, and End Result (SEER) database. Comparisons with the general population were done using the National Center for Disease Control registry. Results: One thousand three hundred eighty-one suicides among 884,529 patients were identified, with a standardized mortality ratio (SMR) of 1.53 (95{\%} CI, 1.13–1.33) compared to the general population. No statistically significant difference in suicide rate was found with respect to age, marital status, socio-economic status, surgical intervention, histologic subtype, or stage at diagnosis. Within the CRC population, Whites were significantly more likely to commit suicide than non-Whites (OR, 2.28; 95{\%} CI, 1.89–2.75; P < 0.001), and males were significantly more likely than females (OR, 5.635; 95{\%} CI, 4.85–6.54; P < 0.001). Most suicides occurred in patients with distal lesions in the sigmoid/rectosigmoid junction (P < 0.001). SMRs for CRC patients were 4.24 for females (95{\%} CI, 3.69–4.86), 1.35 for males (95{\%} CI, 1.28–1.43), 0.38 for African-Americans (95{\%} CI, 0.28–0.52), 1.77 for Whites (95{\%} CI, 1.68–1.87), and 0.90 for other races (95{\%} CI, 0.72–1.12). Conclusion: Identification of risk factors associated with suicide among patients with CRC is an important step in developing screening strategies and management of psychosocial stressors. These results could be helpful in formulating a comprehensive suicide risk scoring system for screening all cancer patients.",
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AU - Walsh, Nathaniel J.

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AU - Bishop, Jessica L.

AU - Kruse, Edward James

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N2 - Purpose: While increased suicidal tendencies among cancer patients have been well documented, this study aims to examine suicide rates and factors associated with suicide specifically in patients with colorectal cancer (CRC). Methods: Patients diagnosed with CRC between the years of 1988–2010 were selected from the Surveillance, Epidemiology, and End Result (SEER) database. Comparisons with the general population were done using the National Center for Disease Control registry. Results: One thousand three hundred eighty-one suicides among 884,529 patients were identified, with a standardized mortality ratio (SMR) of 1.53 (95% CI, 1.13–1.33) compared to the general population. No statistically significant difference in suicide rate was found with respect to age, marital status, socio-economic status, surgical intervention, histologic subtype, or stage at diagnosis. Within the CRC population, Whites were significantly more likely to commit suicide than non-Whites (OR, 2.28; 95% CI, 1.89–2.75; P < 0.001), and males were significantly more likely than females (OR, 5.635; 95% CI, 4.85–6.54; P < 0.001). Most suicides occurred in patients with distal lesions in the sigmoid/rectosigmoid junction (P < 0.001). SMRs for CRC patients were 4.24 for females (95% CI, 3.69–4.86), 1.35 for males (95% CI, 1.28–1.43), 0.38 for African-Americans (95% CI, 0.28–0.52), 1.77 for Whites (95% CI, 1.68–1.87), and 0.90 for other races (95% CI, 0.72–1.12). Conclusion: Identification of risk factors associated with suicide among patients with CRC is an important step in developing screening strategies and management of psychosocial stressors. These results could be helpful in formulating a comprehensive suicide risk scoring system for screening all cancer patients.

AB - Purpose: While increased suicidal tendencies among cancer patients have been well documented, this study aims to examine suicide rates and factors associated with suicide specifically in patients with colorectal cancer (CRC). Methods: Patients diagnosed with CRC between the years of 1988–2010 were selected from the Surveillance, Epidemiology, and End Result (SEER) database. Comparisons with the general population were done using the National Center for Disease Control registry. Results: One thousand three hundred eighty-one suicides among 884,529 patients were identified, with a standardized mortality ratio (SMR) of 1.53 (95% CI, 1.13–1.33) compared to the general population. No statistically significant difference in suicide rate was found with respect to age, marital status, socio-economic status, surgical intervention, histologic subtype, or stage at diagnosis. Within the CRC population, Whites were significantly more likely to commit suicide than non-Whites (OR, 2.28; 95% CI, 1.89–2.75; P < 0.001), and males were significantly more likely than females (OR, 5.635; 95% CI, 4.85–6.54; P < 0.001). Most suicides occurred in patients with distal lesions in the sigmoid/rectosigmoid junction (P < 0.001). SMRs for CRC patients were 4.24 for females (95% CI, 3.69–4.86), 1.35 for males (95% CI, 1.28–1.43), 0.38 for African-Americans (95% CI, 0.28–0.52), 1.77 for Whites (95% CI, 1.68–1.87), and 0.90 for other races (95% CI, 0.72–1.12). Conclusion: Identification of risk factors associated with suicide among patients with CRC is an important step in developing screening strategies and management of psychosocial stressors. These results could be helpful in formulating a comprehensive suicide risk scoring system for screening all cancer patients.

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