Clinical and pathologic findings of myocarditis in two families with dilated cardiomyopathy

John B. O'Connell, Robert E. Fowles, John A. Robinson, Ramiah Subramanian, Robert E. Henkin, Rolf M. Gunnar

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The use of endomyocardial biopsy and gallium-67 scans in patients with dilated cardiomyopathy (DCM) has demonstrated the presence of myocardial inflammation in a subset of patients. A family with DCM was studied with endomyocardial biopsy and gallium-67 scanning; both identified the presence of myocarditis in the proband. Evaluation of histologic sections from decreased family members revealed myocarditis as the principal pathologic finding. This patient identified during life demonstrated a defect in suppressor lymphocytic function and improved with immunosuppressive therapy. A second family with DCM was discovered when postmortem examination of the proband and his father's heart showed myocarditis. A living sibling was identified with asymptomatic myocardial dysfunction. Longitudinal follow-up of surviving members of both families are in progress. This study indicates that thorough diagnostic evaluation of all patients with familial DCM should be pursued to identify subgroups with potentially treatable inflammation.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalAmerican Heart Journal
Volume107
Issue number1
DOIs
StatePublished - Jan 1 1984

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Myocarditis
Dilated Cardiomyopathy
Gallium
Inflammation
Biopsy
Immunosuppressive Agents
Fathers
Siblings
Autopsy
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

O'Connell, J. B., Fowles, R. E., Robinson, J. A., Subramanian, R., Henkin, R. E., & Gunnar, R. M. (1984). Clinical and pathologic findings of myocarditis in two families with dilated cardiomyopathy. American Heart Journal, 107(1), 127-135. https://doi.org/10.1016/0002-8703(84)90146-7

Clinical and pathologic findings of myocarditis in two families with dilated cardiomyopathy. / O'Connell, John B.; Fowles, Robert E.; Robinson, John A.; Subramanian, Ramiah; Henkin, Robert E.; Gunnar, Rolf M.

In: American Heart Journal, Vol. 107, No. 1, 01.01.1984, p. 127-135.

Research output: Contribution to journalArticle

O'Connell, JB, Fowles, RE, Robinson, JA, Subramanian, R, Henkin, RE & Gunnar, RM 1984, 'Clinical and pathologic findings of myocarditis in two families with dilated cardiomyopathy', American Heart Journal, vol. 107, no. 1, pp. 127-135. https://doi.org/10.1016/0002-8703(84)90146-7
O'Connell JB, Fowles RE, Robinson JA, Subramanian R, Henkin RE, Gunnar RM. Clinical and pathologic findings of myocarditis in two families with dilated cardiomyopathy. American Heart Journal. 1984 Jan 1;107(1):127-135. https://doi.org/10.1016/0002-8703(84)90146-7
O'Connell, John B. ; Fowles, Robert E. ; Robinson, John A. ; Subramanian, Ramiah ; Henkin, Robert E. ; Gunnar, Rolf M. / Clinical and pathologic findings of myocarditis in two families with dilated cardiomyopathy. In: American Heart Journal. 1984 ; Vol. 107, No. 1. pp. 127-135.
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