Abstract
To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 639-646 |
| Number of pages | 8 |
| Journal | Cancer Investigation |
| Volume | 35 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 26 2017 |
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Keywords
- 21-Gene recurrence score
- Breast cancer
- Cancer stem cells
- Recurrence risk
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers. / Xiao, Guodong; Meng, Jinying; Zhang, Jing; Li, Gang; Du, Ning; Qin, Sida; Wang, Jichang; Xu, Chongwen; Ren, Hong; Tang, Shou-Ching; Sun, Xin.
In: Cancer Investigation, Vol. 35, No. 10, 26.11.2017, p. 639-646.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers
AU - Xiao, Guodong
AU - Meng, Jinying
AU - Zhang, Jing
AU - Li, Gang
AU - Du, Ning
AU - Qin, Sida
AU - Wang, Jichang
AU - Xu, Chongwen
AU - Ren, Hong
AU - Tang, Shou-Ching
AU - Sun, Xin
PY - 2017/11/26
Y1 - 2017/11/26
N2 - To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.
AB - To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.
KW - 21-Gene recurrence score
KW - Breast cancer
KW - Cancer stem cells
KW - Recurrence risk
UR - http://www.scopus.com/inward/record.url?scp=85038641620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038641620&partnerID=8YFLogxK
U2 - 10.1080/07357907.2017.1405015
DO - 10.1080/07357907.2017.1405015
M3 - Article
C2 - 29243989
AN - SCOPUS:85038641620
VL - 35
SP - 639
EP - 646
JO - Cancer Investigation
JF - Cancer Investigation
SN - 0735-7907
IS - 10
ER -