Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers

Guodong Xiao; Jinying Meng; Jing Zhang; Gang Li; Ning Du; Sida Qin; Jichang Wang; Chongwen Xu; Hong Ren; Shou-Ching Tang; Xin Sun

doi:10.1080/07357907.2017.1405015

Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers

Guodong Xiao, Jinying Meng, Jing Zhang, Gang Li, Ning Du, Sida Qin, Jichang Wang, Chongwen Xu, Hong Ren, Shou-Ching Tang, Xin Sun

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.

Original language	English (US)
Pages (from-to)	639-646
Number of pages	8
Journal	Cancer Investigation
Volume	35
Issue number	10
DOIs	https://doi.org/10.1080/07357907.2017.1405015
State	Published - Nov 26 2017

Keywords

21-Gene recurrence score
Breast cancer
Cancer stem cells
Recurrence risk

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1080/07357907.2017.1405015

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Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers. / Xiao, Guodong; Meng, Jinying; Zhang, Jing; Li, Gang; Du, Ning; Qin, Sida; Wang, Jichang; Xu, Chongwen; Ren, Hong; Tang, Shou-Ching; Sun, Xin.

In: Cancer Investigation, Vol. 35, No. 10, 26.11.2017, p. 639-646.

Research output: Contribution to journal › Article › peer-review

Xiao, Guodong ; Meng, Jinying ; Zhang, Jing ; Li, Gang ; Du, Ning ; Qin, Sida ; Wang, Jichang ; Xu, Chongwen ; Ren, Hong ; Tang, Shou-Ching ; Sun, Xin. / Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers. In: Cancer Investigation. 2017 ; Vol. 35, No. 10. pp. 639-646.

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title = "Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers",

abstract = "To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.",

keywords = "21-Gene recurrence score, Breast cancer, Cancer stem cells, Recurrence risk",

author = "Guodong Xiao and Jinying Meng and Jing Zhang and Gang Li and Ning Du and Sida Qin and Jichang Wang and Chongwen Xu and Hong Ren and Shou-Ching Tang and Xin Sun",

note = "Funding Information: This experiment was mainly supported by National Natural Science Foundation for Young Scientists of China, grant No. 81602597 (Referred to Xin Sun), National Natural Science Foundation of China, grant No. 81272418 (Referred to Hong Ren). This work was also supported in part by National Natural Science Foundation for Young Scientists of China, grant No. 81402506 (Referred to Sida Qin), Natural Science Foundation of Shaanxi Province, grant No. 2016JM8007 (Referred to Jing Zhang).",

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doi = "10.1080/07357907.2017.1405015",

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AU - Qin, Sida

AU - Wang, Jichang

AU - Xu, Chongwen

AU - Ren, Hong

AU - Tang, Shou-Ching

AU - Sun, Xin

N1 - Funding Information: This experiment was mainly supported by National Natural Science Foundation for Young Scientists of China, grant No. 81602597 (Referred to Xin Sun), National Natural Science Foundation of China, grant No. 81272418 (Referred to Hong Ren). This work was also supported in part by National Natural Science Foundation for Young Scientists of China, grant No. 81402506 (Referred to Sida Qin), Natural Science Foundation of Shaanxi Province, grant No. 2016JM8007 (Referred to Jing Zhang).

PY - 2017/11/26

Y1 - 2017/11/26

N2 - To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.

AB - To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.

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KW - Cancer stem cells

KW - Recurrence risk

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Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers

Abstract

Keywords

ASJC Scopus subject areas

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