Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers

Guodong Xiao, Jinying Meng, Jing Zhang, Gang Li, Ning Du, Sida Qin, Jichang Wang, Chongwen Xu, Hong Ren, Shou-Ching Tang, Xin Sun

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.

Original languageEnglish (US)
Pages (from-to)639-646
Number of pages8
JournalCancer Investigation
Volume35
Issue number10
DOIs
StatePublished - Nov 26 2017

Keywords

  • 21-Gene recurrence score
  • Breast cancer
  • Cancer stem cells
  • Recurrence risk

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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