Clinical aspects of Parkinson disease

Kapil Dev Sethi

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Parkinson disease is a slowly progressive neurodegenerative disorder with a varied clinical picture and a variable rate of progression. Recently, there have been some studies conducted to assess the diagnostic accuracy and other clinical aspects of the disease. In the absence of a biomarker the clinical diagnosis is imprecise. This leads to a significant number of misdiagnoses, especially in early disease. Assessment of the clinical features suggests that an accuracy of 90% may be the highest that can be expected using current diagnostic criteria. In addition to bradykinesia, which is a core symptom, different types of tremors occur. Whereas the rest tremor is characteristic, action tremor, re-emergent tremor and orthostatic tremor may occur in Parkinson disease. Symptomatic treatments are quite effective in early disease but clinical course is complicated by the appearance of motor fluctuations and dyskinesias in more advanced disease. Non-motor complications, such as cognitive, psychiatric and autonomic problems, become bothersome and disabling in some patients.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalCurrent Opinion in Neurology
Volume15
Issue number4
DOIs
StatePublished - Aug 10 2002

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Tremor
Parkinson Disease
Hypokinesia
Dyskinesias
Diagnostic Errors
Neurodegenerative Diseases
Psychiatry
Biomarkers

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Clinical aspects of Parkinson disease. / Sethi, Kapil Dev.

In: Current Opinion in Neurology, Vol. 15, No. 4, 10.08.2002, p. 457-460.

Research output: Contribution to journalReview article

Sethi, Kapil Dev. / Clinical aspects of Parkinson disease. In: Current Opinion in Neurology. 2002 ; Vol. 15, No. 4. pp. 457-460.
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