Clinical course and outcome of patients with hodgkin's disease who progress after autologous transplantation

Mary Varterasian, Voravit Ratanatharathorn, Joseph P. Uberti, Chatchada Karanes, Esteban Abella, Feroze Momin, Claude Kasten-Sportes, Ayad Al-Katib, Lawrence Lum, Lance K. Heilbrun, Lyle L. Sensenbrenner

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Twenty-six of fifty-eight patients undergoing autologous bone marrow transplantation (autoBMT) or peripheral stem cell transplantation (PSCT) for Hodgkin's disease had progression of lymphoma (Hodgkin's or non-Hodgkin's) during the course of their follow-up. The majority of progressions, 81% (21/26), occurred within the first year of transplant; 12% (3/26) occurred at three years or more. Three patients developed a non-Hodgkin's lymphoma; all B-cell tumors primarily involving the gastrointestinal tract. The majority of patients (23/26) received at least one therapy after progression and 65% (17/26) of patients received multiple therapies. One patient who received a second BMT is alive without evidence of disease at 49 months following the second autologous BMT. The median survival for the entire group is 11 months. Forty-six percent (12/26) of patients survived more than one year and twenty-three percent (6/26) survived more than two years after disease progression. Post-progression survival is significantly related to time to progression.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalLeukemia and Lymphoma
Volume20
Issue number1-2
DOIs
StatePublished - Jan 1 1995

Keywords

  • AutoBMT
  • Hodgkin's disease
  • Progression
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Varterasian, M., Ratanatharathorn, V., Uberti, J. P., Karanes, C., Abella, E., Momin, F., Kasten-Sportes, C., Al-Katib, A., Lum, L., Heilbrun, L. K., & Sensenbrenner, L. L. (1995). Clinical course and outcome of patients with hodgkin's disease who progress after autologous transplantation. Leukemia and Lymphoma, 20(1-2), 59-65. https://doi.org/10.3109/10428199509054754