Clinical evaluation of a 3% hydrogen peroxide tooth-whitening Gel

Michael L Myers, William D. Browning, Mary C. Downey, Steven T. Hackman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: The purpose of this randomized double-blind investigation was to clinically evaluate the effectiveness of a commercially available 3% hydrogen peroxide tooth-whitening material (ADS Tooth Whitening Gel, Applied Dental Sciences, Inc., Lee, MA). The material was used over 2 weeks in a dentist-supervised, patient-applied application. Materials and Methods: The evaluation was carried out in accordance with American Dental Association (ADA) Council on Scientific Affairs Acceptance Program Guidelines for Home-Use Tooth Whitening Products (May 1998). Sixty-five participants were randomized into two groups (active and placebo) for a double-blind, placebo-controlled study. A custom application tray, scalloped without reservoirs, was fabricated for each participant. Tooth shades were documented by matching with the Vita shade guide ordered according to value and assigned a numeric ranking from 1 to 16, darkest to lightest. Participants were supplied with the treatment solutions to use in the application tray. Duration of active treatment was 30 minutes 3 times a day for 2 weeks. Participants were evaluated at baseline, 1 week and 2 weeks treatment, and 12 and 26 weeks post-treatment. The statistical analysis used at each time point to determine the difference between the active and placebo groups based on the change in value was the two-sample t-test. Plaque and soft tissue indices were also recorded. Results: The teeth treated with 3% hydrogen peroxide were significantly lighter at 2, 12, and 26 weeks (p ≤ .0140, .0004, and .0001, respectively) compared with the placebo group. The mean shade change was 4.2 Vita shade tabs at 2 weeks. At 26 weeks (6 months), the degree of whitening was 4.1 tabs.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalJournal of Esthetic and Restorative Dentistry
Volume15
Issue number1
StatePublished - Dec 1 2003

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Tooth Bleaching
Hydrogen Peroxide
Gels
Placebos
Tooth
American Dental Association
Therapeutics
Dentists
Guidelines

ASJC Scopus subject areas

  • Dentistry(all)

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Clinical evaluation of a 3% hydrogen peroxide tooth-whitening Gel. / Myers, Michael L; Browning, William D.; Downey, Mary C.; Hackman, Steven T.

In: Journal of Esthetic and Restorative Dentistry, Vol. 15, No. 1, 01.12.2003, p. 50-55.

Research output: Contribution to journalArticle

Myers, Michael L ; Browning, William D. ; Downey, Mary C. ; Hackman, Steven T. / Clinical evaluation of a 3% hydrogen peroxide tooth-whitening Gel. In: Journal of Esthetic and Restorative Dentistry. 2003 ; Vol. 15, No. 1. pp. 50-55.
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