Abstract
Aim: Forty percent of patients with higher-risk myelodysplastic syndromes (HR-MDS) transform to acute myeloid leukemia (AML). Materials & methods: This retrospective study assessed the impact of HR-MDS transformation to AML on OS in a 6-month landmark analysis and the results were validated using a time-varying analysis. Results: The rate of AML transformation was 26.9% at 1 year. Patients who transformed to AML had a higher risk of death than patients who did not in the 6-month landmark analysis (HR: 1.82; p: 0.0072) and time-varying analysis at 1 year (HR: 2.85; p < 0.0001). Patients treated with azacitidine and decitabine in first-line therapy had similar results. Conclusion: HR-MDS transformation to AML is associated with inferior OS in patients with HR-MDS initiating first-line therapy.
Original language | English (US) |
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Pages (from-to) | 4017-4029 |
Number of pages | 13 |
Journal | Future Oncology |
Volume | 18 |
Issue number | 36 |
DOIs | |
State | Published - Nov 1 2022 |
Keywords
- AML
- MDS
- higher-risk
- overall survival
- transformation
ASJC Scopus subject areas
- Oncology
- Cancer Research