TY - JOUR
T1 - Clinical outcomes in patients on preinjury ibuprofen with traumatic brain injury
AU - Zangbar, Bardiya
AU - Pandit, Viraj
AU - Rhee, Peter
AU - Khalil, Mazhar
AU - Kulvatunyou, Narong
AU - OKeeffe, Terence
AU - Tang, Andrew
AU - Gries, Lynn
AU - Green, Donald J.
AU - Friese, Randall S.
AU - Joseph, Bellal
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Background The aim of our study was to evaluate the clinical outcomes in patients on preinjury Ibuprofen with traumatic brain injury. Methods We performed a 2-year analysis of all patients on prehospital Ibuprofen with traumatic brain injury and intracranial hemorrhage. Patients on preinjury Ibuprofen were matched using propensity score matching to patients not on Ibuprofen in a 1:2 ratio for age, Glasgow Coma Scale, head-abbreviated injury scale, injury severity score, International Normalized Ratio, and neurologic examination. Outcome measures were progression on repeat head computed tomography (RHCT) and neurosurgical intervention. Results A total of 195 matched (Ibuprofen 65, no-Ibuprofen 130) patients were included. There was no difference in the progression on RHCT (Ibuprofen 18% vs no-Ibuprofen 24%; P =.50). The neurosurgical intervention rate was 18.9% (n = 37). There was no difference for need for neurosurgical intervention (26% vs 16%; P =.10) between the 2 groups. Conclusions In a matched cohort of trauma patients, preinjury Ibuprofen use was not associated with progression of initial intracranial hemorrhage and the need for neurosurgical intervention. Preinjury use of Ibuprofen as an independent variable should not warrant the need for a routine RHCT scan.
AB - Background The aim of our study was to evaluate the clinical outcomes in patients on preinjury Ibuprofen with traumatic brain injury. Methods We performed a 2-year analysis of all patients on prehospital Ibuprofen with traumatic brain injury and intracranial hemorrhage. Patients on preinjury Ibuprofen were matched using propensity score matching to patients not on Ibuprofen in a 1:2 ratio for age, Glasgow Coma Scale, head-abbreviated injury scale, injury severity score, International Normalized Ratio, and neurologic examination. Outcome measures were progression on repeat head computed tomography (RHCT) and neurosurgical intervention. Results A total of 195 matched (Ibuprofen 65, no-Ibuprofen 130) patients were included. There was no difference in the progression on RHCT (Ibuprofen 18% vs no-Ibuprofen 24%; P =.50). The neurosurgical intervention rate was 18.9% (n = 37). There was no difference for need for neurosurgical intervention (26% vs 16%; P =.10) between the 2 groups. Conclusions In a matched cohort of trauma patients, preinjury Ibuprofen use was not associated with progression of initial intracranial hemorrhage and the need for neurosurgical intervention. Preinjury use of Ibuprofen as an independent variable should not warrant the need for a routine RHCT scan.
KW - Ibuprofen
KW - Motrin
KW - Neurosurgical Intervention
KW - Nonsteroidal anti-inflammatory drugs
KW - Repeat head computed tomography
KW - Traumatic brain injury
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U2 - 10.1016/j.amjsurg.2014.05.027
DO - 10.1016/j.amjsurg.2014.05.027
M3 - Article
C2 - 25190545
AN - SCOPUS:84930064087
SN - 0002-9610
VL - 209
SP - 921
EP - 926
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 6
ER -