Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0 T versus 1.5 T MRI-based treatment planning: Have we finally optimised detection of occult brain metastases?

Amritraj G. Loganathan, Michael D. Chan, Natalie Alphonse, Ann M. Peiffer, Annette Johnson, Kevin P. McMullen, James J. Urbanic, Paul A. Saconn, J. Daniel Bourland, Michael T. Munley, Edward G. Shaw, Stephen B. Tatter, Thomas L. Ellis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction The goal of this study was to determine if clinically relevant endpoints were changed by improved MRI resolution during radiosurgical treatment planning. Methods and Materials Between 2003 and 2008, 200 consecutive patients with brain metastases treated with Gamma Knife radiosurgery (GKRS) using either 1.5 T or 3.0 T MRI for radiosurgical treatment planning were retrospectively analysed. The number of previously undetected metastases at time of radiosurgery, distant brain failures, time delay to whole brain radiotherapy (WBRT), overall survival and likelihood of neurological death were determined. Results Additional metastases were detected in 31.3% and 24.5% of patients at time of radiosurgery with 3.0 T and 1.5 T MRI, respectively (P = 0.27). Patients with multiple metastases at diagnostic scan were more likely to have additional metastases detected by 3.0 T MRI (P < 0.1). Median time to distant brain failure was 4.87 months and 5.43 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.44). Median time to WBRT was 5.8 months and 5.3 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.87). Median survival was 6.4 months for the 3.0 T cohort, and 6.1 months for the 1.5 T cohort (P = 0.71). Likelihood of neurological death was 25.3% and 16.7% for the 3.0 and 1.5 T populations, respectively (P = 0.26). Conclusions The 3.0 T MRI-based treatment planning for GKRS did not appear to affect the likelihood of distant brain failure, the need for WBRT or the likelihood of neurological death in this series.

Original languageEnglish (US)
Pages (from-to)554-560
Number of pages7
JournalJournal of Medical Imaging and Radiation Oncology
Volume56
Issue number5
DOIs
StatePublished - Oct 1 2012

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Radiosurgery
Neoplasm Metastasis
Brain
Radiotherapy
Therapeutics
Survival
Population

Keywords

  • 3 Tesla MRI
  • brain metastases
  • radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0 T versus 1.5 T MRI-based treatment planning : Have we finally optimised detection of occult brain metastases? / Loganathan, Amritraj G.; Chan, Michael D.; Alphonse, Natalie; Peiffer, Ann M.; Johnson, Annette; McMullen, Kevin P.; Urbanic, James J.; Saconn, Paul A.; Bourland, J. Daniel; Munley, Michael T.; Shaw, Edward G.; Tatter, Stephen B.; Ellis, Thomas L.

In: Journal of Medical Imaging and Radiation Oncology, Vol. 56, No. 5, 01.10.2012, p. 554-560.

Research output: Contribution to journalArticle

Loganathan, Amritraj G. ; Chan, Michael D. ; Alphonse, Natalie ; Peiffer, Ann M. ; Johnson, Annette ; McMullen, Kevin P. ; Urbanic, James J. ; Saconn, Paul A. ; Bourland, J. Daniel ; Munley, Michael T. ; Shaw, Edward G. ; Tatter, Stephen B. ; Ellis, Thomas L. / Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0 T versus 1.5 T MRI-based treatment planning : Have we finally optimised detection of occult brain metastases?. In: Journal of Medical Imaging and Radiation Oncology. 2012 ; Vol. 56, No. 5. pp. 554-560.
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abstract = "Introduction The goal of this study was to determine if clinically relevant endpoints were changed by improved MRI resolution during radiosurgical treatment planning. Methods and Materials Between 2003 and 2008, 200 consecutive patients with brain metastases treated with Gamma Knife radiosurgery (GKRS) using either 1.5 T or 3.0 T MRI for radiosurgical treatment planning were retrospectively analysed. The number of previously undetected metastases at time of radiosurgery, distant brain failures, time delay to whole brain radiotherapy (WBRT), overall survival and likelihood of neurological death were determined. Results Additional metastases were detected in 31.3{\%} and 24.5{\%} of patients at time of radiosurgery with 3.0 T and 1.5 T MRI, respectively (P = 0.27). Patients with multiple metastases at diagnostic scan were more likely to have additional metastases detected by 3.0 T MRI (P < 0.1). Median time to distant brain failure was 4.87 months and 5.43 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.44). Median time to WBRT was 5.8 months and 5.3 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.87). Median survival was 6.4 months for the 3.0 T cohort, and 6.1 months for the 1.5 T cohort (P = 0.71). Likelihood of neurological death was 25.3{\%} and 16.7{\%} for the 3.0 and 1.5 T populations, respectively (P = 0.26). Conclusions The 3.0 T MRI-based treatment planning for GKRS did not appear to affect the likelihood of distant brain failure, the need for WBRT or the likelihood of neurological death in this series.",
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T1 - Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0 T versus 1.5 T MRI-based treatment planning

T2 - Have we finally optimised detection of occult brain metastases?

AU - Loganathan, Amritraj G.

AU - Chan, Michael D.

AU - Alphonse, Natalie

AU - Peiffer, Ann M.

AU - Johnson, Annette

AU - McMullen, Kevin P.

AU - Urbanic, James J.

AU - Saconn, Paul A.

AU - Bourland, J. Daniel

AU - Munley, Michael T.

AU - Shaw, Edward G.

AU - Tatter, Stephen B.

AU - Ellis, Thomas L.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Introduction The goal of this study was to determine if clinically relevant endpoints were changed by improved MRI resolution during radiosurgical treatment planning. Methods and Materials Between 2003 and 2008, 200 consecutive patients with brain metastases treated with Gamma Knife radiosurgery (GKRS) using either 1.5 T or 3.0 T MRI for radiosurgical treatment planning were retrospectively analysed. The number of previously undetected metastases at time of radiosurgery, distant brain failures, time delay to whole brain radiotherapy (WBRT), overall survival and likelihood of neurological death were determined. Results Additional metastases were detected in 31.3% and 24.5% of patients at time of radiosurgery with 3.0 T and 1.5 T MRI, respectively (P = 0.27). Patients with multiple metastases at diagnostic scan were more likely to have additional metastases detected by 3.0 T MRI (P < 0.1). Median time to distant brain failure was 4.87 months and 5.43 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.44). Median time to WBRT was 5.8 months and 5.3 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.87). Median survival was 6.4 months for the 3.0 T cohort, and 6.1 months for the 1.5 T cohort (P = 0.71). Likelihood of neurological death was 25.3% and 16.7% for the 3.0 and 1.5 T populations, respectively (P = 0.26). Conclusions The 3.0 T MRI-based treatment planning for GKRS did not appear to affect the likelihood of distant brain failure, the need for WBRT or the likelihood of neurological death in this series.

AB - Introduction The goal of this study was to determine if clinically relevant endpoints were changed by improved MRI resolution during radiosurgical treatment planning. Methods and Materials Between 2003 and 2008, 200 consecutive patients with brain metastases treated with Gamma Knife radiosurgery (GKRS) using either 1.5 T or 3.0 T MRI for radiosurgical treatment planning were retrospectively analysed. The number of previously undetected metastases at time of radiosurgery, distant brain failures, time delay to whole brain radiotherapy (WBRT), overall survival and likelihood of neurological death were determined. Results Additional metastases were detected in 31.3% and 24.5% of patients at time of radiosurgery with 3.0 T and 1.5 T MRI, respectively (P = 0.27). Patients with multiple metastases at diagnostic scan were more likely to have additional metastases detected by 3.0 T MRI (P < 0.1). Median time to distant brain failure was 4.87 months and 5.43 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.44). Median time to WBRT was 5.8 months and 5.3 months for the 3.0 T and 1.5 T cohorts, respectively (P = 0.87). Median survival was 6.4 months for the 3.0 T cohort, and 6.1 months for the 1.5 T cohort (P = 0.71). Likelihood of neurological death was 25.3% and 16.7% for the 3.0 and 1.5 T populations, respectively (P = 0.26). Conclusions The 3.0 T MRI-based treatment planning for GKRS did not appear to affect the likelihood of distant brain failure, the need for WBRT or the likelihood of neurological death in this series.

KW - 3 Tesla MRI

KW - brain metastases

KW - radiosurgery

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