Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous t-cell lymphoma: A review on current efficacy and safety data

Kendall Liner, Celeste Brown, Laura Y. McGirt

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. The authors in this review found that while the gel formulation may result in a decrease of allergic contact dermatitis, this advantage has been replaced by a higher number of irritant contact reactions and a decrease in complete response rate. The gel formulation has a complete response rate of 13.8%, which is a decrease in efficacy when compared to aqueous-based preparations of similar concentrations.

Original languageEnglish (US)
Pages (from-to)241-254
Number of pages14
JournalDrug Design, Development and Therapy
Volume12
DOIs
StatePublished - Jan 31 2018

Keywords

  • CTCL
  • Cutaneous T-cell lymphoma
  • Mechlorethamine gel
  • Mycosis fungoides
  • Nitrogen mustard
  • Valchlor®

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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