TY - JOUR
T1 - Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock
T2 - 2007 update from the American College of Critical Care Medicine
AU - Brierley, Joe
AU - Carcillo, Joseph A.
AU - Choong, Karen
AU - Cornell, Tim
AU - Decaen, Allan
AU - Deymann, Andreas
AU - Doctor, Allan
AU - Davis, Alan
AU - Duff, John
AU - Dugas, Marc Andre
AU - Duncan, Alan
AU - Evans, Barry
AU - Feldman, Jonathan
AU - Felmet, Kathryn
AU - Fisher, Lyle E
AU - Frankel, Lorry
AU - Jeffries, Howard
AU - Greenwald, Bruce
AU - Gutierrez, Juan
AU - Hall, Mark
AU - Han, Yong Y.
AU - Hanson, James
AU - Hazelzet, Jan
AU - Hernan, Lynn
AU - Kiff, Jane
AU - Kissoon, Niranjan
AU - Kon, Alexander
AU - Irazusta, Jose
AU - Lin, John
AU - Lorts, Angie
AU - Mariscalco, Michelle
AU - Mehta, Renuka
AU - Nadel, Simon
AU - Nguyen, Trung
AU - Nicholson, Carol
AU - Peters, Mark
AU - Okhuysen-Cawley, Regina
AU - Poulton, Tom
AU - Relves, Monica
AU - Rodriguez, Agustin
AU - Rozenfeld, Ranna
AU - Schnitzler, Eduardo
AU - Shanley, Tom
AU - Skache, Sara
AU - Skippen, Peter
AU - Torres, Adalberto
AU - Von Dessauer, Bettina
AU - Weingarten, Jacki
AU - Yeh, Timothy
AU - Zaritsky, Arno
AU - Stojadinovic, Bonnie
AU - Zimmerman, Jerry
AU - Zuckerberg, Aaron
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2009/2
Y1 - 2009/2
N2 - BACKGROUND:: The Institute of Medicine calls for the use of clinical guidelines and practice parameters to promote "best practices" and to improve patient outcomes. OBJECTIVE:: 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock. PARTICIPANTS:: Society of Critical Care Medicine members with special interest in neonatal and pediatric septic shock were identified from general solicitation at the Society of Critical Care Medicine Educational and Scientific Symposia (2001-2006). METHODS:: The Pubmed/MEDLINE literature database (1966-2006) was searched using the keywords and phrases: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation (ECMO), and American College of Critical Care Medicine guidelines. Best practice centers that reported best outcomes were identified and their practices examined as models of care. Using a modified Delphi method, 30 experts graded new literature. Over 30 additional experts then reviewed the updated recommendations. The document was subsequently modified until there was greater than 90% expert consensus. RESULTS:: The 2002 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and AHA sanctioned recommendations. Centers that implemented the 2002 guidelines reported best practice outcomes (hospital mortality 1%-3% in previously healthy, and 7%-10% in chronically ill children). Early use of 2002 guidelines was associated with improved outcome in the community hospital emergency department (number needed to treat = 3.3) and tertiary pediatric intensive care setting (number needed to treat = 3.6); every hour that went by without guideline adherence was associated with a 1.4-fold increased mortality risk. The updated 2007 guidelines continue to recognize an increased likelihood that children with septic shock, compared with adults, require 1) proportionally larger quantities of fluid, 2) inotrope and vasodilator therapies, 3) hydrocortisone for absolute adrenal insufficiency, and 4) ECMO for refractory shock. The major new recommendation in the 2007 update is earlier use of inotrope support through peripheral access until central access is attained. CONCLUSION:: The 2007 update continues to emphasize early use of age-specific therapies to attain time-sensitive goals, specifically recommending 1) first hour fluid resuscitation and inotrope therapy directed to goals of threshold heart rates, normal blood pressure, and capillary refill ≤2 secs, and 2) subsequent intensive care unit hemodynamic support directed to goals of central venous oxygen saturation >70% and cardiac index 3.3-6.0 L/min/m.
AB - BACKGROUND:: The Institute of Medicine calls for the use of clinical guidelines and practice parameters to promote "best practices" and to improve patient outcomes. OBJECTIVE:: 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock. PARTICIPANTS:: Society of Critical Care Medicine members with special interest in neonatal and pediatric septic shock were identified from general solicitation at the Society of Critical Care Medicine Educational and Scientific Symposia (2001-2006). METHODS:: The Pubmed/MEDLINE literature database (1966-2006) was searched using the keywords and phrases: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation (ECMO), and American College of Critical Care Medicine guidelines. Best practice centers that reported best outcomes were identified and their practices examined as models of care. Using a modified Delphi method, 30 experts graded new literature. Over 30 additional experts then reviewed the updated recommendations. The document was subsequently modified until there was greater than 90% expert consensus. RESULTS:: The 2002 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and AHA sanctioned recommendations. Centers that implemented the 2002 guidelines reported best practice outcomes (hospital mortality 1%-3% in previously healthy, and 7%-10% in chronically ill children). Early use of 2002 guidelines was associated with improved outcome in the community hospital emergency department (number needed to treat = 3.3) and tertiary pediatric intensive care setting (number needed to treat = 3.6); every hour that went by without guideline adherence was associated with a 1.4-fold increased mortality risk. The updated 2007 guidelines continue to recognize an increased likelihood that children with septic shock, compared with adults, require 1) proportionally larger quantities of fluid, 2) inotrope and vasodilator therapies, 3) hydrocortisone for absolute adrenal insufficiency, and 4) ECMO for refractory shock. The major new recommendation in the 2007 update is earlier use of inotrope support through peripheral access until central access is attained. CONCLUSION:: The 2007 update continues to emphasize early use of age-specific therapies to attain time-sensitive goals, specifically recommending 1) first hour fluid resuscitation and inotrope therapy directed to goals of threshold heart rates, normal blood pressure, and capillary refill ≤2 secs, and 2) subsequent intensive care unit hemodynamic support directed to goals of central venous oxygen saturation >70% and cardiac index 3.3-6.0 L/min/m.
KW - Guidelines
KW - Sepsis
KW - Severe sepsis
UR - http://www.scopus.com/inward/record.url?scp=66149103003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66149103003&partnerID=8YFLogxK
U2 - 10.1097/CCM.0b013e31819323c6
DO - 10.1097/CCM.0b013e31819323c6
M3 - Article
C2 - 19325359
AN - SCOPUS:66149103003
VL - 37
SP - 666
EP - 688
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 2
ER -