Clinical report - Probiotics and prebiotics in pediatrics

Dan W. Thomas, Frank R. Greer, Jatinder J.S. Bhatia, Steven A. Abrams, Stephen R. Daniels, Marcie Beth Schneider, Janet Silverstein, Nicolas Stettler, Leo A. Heitlinger, Robert D. Baker, David A. Gremse, Roberto Gugig, Jenifer R. Lightdale

Research output: Contribution to journalReview article

270 Citations (Scopus)

Abstract

This clinical report reviews the currently known health benefits of probiotic and prebiotic products, including those added to commercially available infant formula and other food products for use in children. Probiotics are supplements or foods that contain viable microorganisms that cause alterations of the microflora of the host. Use of probiotics has been shown to be modestly effective in randomized clinical trials (RCTs) in (1) treating acute viral gastroenteritis in healthy children; and (2) preventing antibiotic-associated diarrhea in healthy children. There is some evidence that probiotics prevent necrotizing enterocolitis in very low birth weight infants (birth weight between 1000 and 1500 g), but more studies are needed. The results of RCTs in which probiotics were used to treat childhood Helicobacter pylori gastritis, irritable bowel syndrome, chronic ulcerative colitis, and infantile colic, as well as in preventing childhood atopy, although encouraging, are preliminary and require further confirmation. Probiotics have not been proven to be beneficial in treating or preventing human cancers or in treating children with Crohn disease. There are also safety concerns with the use of probiotics in infants and children who are immunocompromised, chronically debilitated, or seriously ill with indwelling medical devices. Prebiotics are supplements or foods that contain a nondigestible food ingredient that selectively stimulates the favorable growth and/or activity of indigenous probiotic bacteria. Human milk contains substantial quantities of prebiotics. There is a paucity of RCTs examining prebiotics in children, although there may be some long-term benefit of prebiotics for the prevention of atopic eczema and common infections in healthy infants. Confirmatory well-designed clinical research studies are necessary.

Original languageEnglish (US)
Pages (from-to)1217-1231
Number of pages15
JournalPediatrics
Volume126
Issue number6
DOIs
StatePublished - Dec 1 2010

Fingerprint

Prebiotics
Probiotics
Pediatrics
Randomized Controlled Trials
Dietary Supplements
Food
Necrotizing Enterocolitis
Very Low Birth Weight Infant
Infant Formula
Colic
Irritable Bowel Syndrome
Gastroenteritis
Human Milk
Insurance Benefits
Gastritis
Atopic Dermatitis
Ulcerative Colitis
Birth Weight
Helicobacter pylori
Crohn Disease

Keywords

  • Nutrition
  • Pediatrics
  • Prebiotics
  • Probiotics
  • Supplements

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Thomas, D. W., Greer, F. R., Bhatia, J. J. S., Abrams, S. A., Daniels, S. R., Schneider, M. B., ... Lightdale, J. R. (2010). Clinical report - Probiotics and prebiotics in pediatrics. Pediatrics, 126(6), 1217-1231. https://doi.org/10.1542/peds.2010-2548

Clinical report - Probiotics and prebiotics in pediatrics. / Thomas, Dan W.; Greer, Frank R.; Bhatia, Jatinder J.S.; Abrams, Steven A.; Daniels, Stephen R.; Schneider, Marcie Beth; Silverstein, Janet; Stettler, Nicolas; Heitlinger, Leo A.; Baker, Robert D.; Gremse, David A.; Gugig, Roberto; Lightdale, Jenifer R.

In: Pediatrics, Vol. 126, No. 6, 01.12.2010, p. 1217-1231.

Research output: Contribution to journalReview article

Thomas, DW, Greer, FR, Bhatia, JJS, Abrams, SA, Daniels, SR, Schneider, MB, Silverstein, J, Stettler, N, Heitlinger, LA, Baker, RD, Gremse, DA, Gugig, R & Lightdale, JR 2010, 'Clinical report - Probiotics and prebiotics in pediatrics', Pediatrics, vol. 126, no. 6, pp. 1217-1231. https://doi.org/10.1542/peds.2010-2548
Thomas DW, Greer FR, Bhatia JJS, Abrams SA, Daniels SR, Schneider MB et al. Clinical report - Probiotics and prebiotics in pediatrics. Pediatrics. 2010 Dec 1;126(6):1217-1231. https://doi.org/10.1542/peds.2010-2548
Thomas, Dan W. ; Greer, Frank R. ; Bhatia, Jatinder J.S. ; Abrams, Steven A. ; Daniels, Stephen R. ; Schneider, Marcie Beth ; Silverstein, Janet ; Stettler, Nicolas ; Heitlinger, Leo A. ; Baker, Robert D. ; Gremse, David A. ; Gugig, Roberto ; Lightdale, Jenifer R. / Clinical report - Probiotics and prebiotics in pediatrics. In: Pediatrics. 2010 ; Vol. 126, No. 6. pp. 1217-1231.
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