Clinical study of tooth shade lightening from dentist-supervised, patient-applied treatment with two 10% carbamide peroxide gels

Roman M. Cibirka, Michael Myers, Mary C. Downey, Steven K. Nelson, William D. Browning, Isaac K. Hawkins, Gene L. Dickinson

Research output: Contribution to journalArticle

25 Scopus citations


Purpose: Prescribed, patient-applied tooth lightening agents, or nightguard vital bleaching, typically utilizes a 10% carbamide peroxide agent applied during nocturnal hours. The purpose of this randomized double-blind study was to compare the amount of tooth color change in two groups of subjects using dentist-supervised, patient-applied 10% carbamide peroxide gel. Materials and Methods: One group used Opalescence® (Ultradent Products Inc., South Jordan, Utah) and the other Nite White Excel® (Discus Dental, Inc., Los Angeles, California). Evaluation of tooth color for the six maxillary anterior teeth was done using a Vita shade guide at baseline, 1, 2, and 4 weeks. Subjects were instructed to apply the gel nocturnally using a custom-made soft tray 8 hours per day for 2 weeks. The 16 tabs of the shade guide were ranked according to value from darkest to lightest. The number (1–16) that correlated to the shade tab selected as the match for each tooth was the outcome variable. A Kruskal-Wallis one way analysis of variance on ranks was used. Results: The test revealed no statistically significant difference between Opalescence® and NiteWhite® Excel for lightening the teeth (p=.807). The color change was still significant after 2 weeks without further bleaching activity. The baseline evaluation of the maxillary incisors and canines for all subjects, regardless of group, demonstrated a significant shade difference, with the canines being darker. This difference was not seen after 2 weeks of active bleaching or at the 4-week evaluation.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalJournal of Esthetic and Restorative Dentistry
Issue number6
Publication statusPublished - Nov 1999


ASJC Scopus subject areas

  • Dentistry(all)

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