Clinically Silent Adrenocorticotropic Hormone−Positive Crooke Cell Adenoma: Case Report and Review of Literature

Nathan Todnem, Ayobami Ward, Sharmila Segar, Amyn Mohammed Rojiani, Scott Y Rahimi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Pituitary adenomas are one of the most common tumors of adulthood; however, subtypes such as Crooke cell adenoma are relatively rare. Case Description: We present the case of a 55-year-old woman who presented with new-onset intermittent headache and dizziness. Clinical and laboratory investigations were not suggestive of corticotroph tumor. However, subsequent computed tomography and magnetic resonance imaging scans revealed the presence of a suprasellar pituitary adenoma displacing the optic chiasma superiorly, with hemorrhage and sellar expansion. The lesion was removed by transsphenoidal surgery and the biopsy confirmed the lesion to be a nonfunctioning pituitary macroadenoma. Further investigation revealed that the specimen demonstrated Crooke hyaline changes, with strong immunoreactivity for adrenocorticotropic hormone. However, initial workup and postoperative testing lacked evidence of Cushing disease. There was no sign of recurrence after 1-year follow-up. Conclusions: Clinically silent Crooke cell adenomas are rare occurrences, and as such we report this case with investigation of past cases.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalWorld Neurosurgery
StatePublished - Nov 2018


  • Adrenocorticotropic hormone–secreting tumors
  • Crooke cell adenoma
  • Macroadenoma
  • Pituitary apoplexy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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