Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia

J. Jankovic; C. Hunter; B. Z. Dolimbek; G. S. Dolimbek; C. H. Adler; A. Brashear; C. L. Comella; M. Gordon; D. E. Riley; Kapil Dev Sethi; C. Singer; M. Stacy; D. Tarsy; M. Z. Atassi

doi:10.1212/01.wnl.0000249308.66959.43

Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia

J. Jankovic, C. Hunter, B. Z. Dolimbek, G. S. Dolimbek, C. H. Adler, A. Brashear, C. L. Comella, M. Gordon, D. E. Riley, Kapil Dev Sethi, C. Singer, M. Stacy, D. Tarsy, M. Z. Atassi

Neurology

Research output: Contribution to journal › Article

65 Scopus citations

Abstract

In this multicenter study of 100 patients with cervical dystonia, we examined the immunogenicity of botulinum toxin type B (BTX-B) and correlated the clinical response with the presence of blocking antibodies (Abs) using a novel mouse protection assay. One-third of the patients who were negative for BTX-B Abs at baseline became positive for BTX-B Abs at last visit. Thus, the high antigenicity of BTX-B limits its long-term efficacy.

Original language	English (US)
Pages (from-to)	2233-2235
Number of pages	3
Journal	Neurology
Volume	67
Issue number	12
DOIs	https://doi.org/10.1212/01.wnl.0000249308.66959.43
State	Published - Dec 1 2006

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ASJC Scopus subject areas

Clinical Neurology

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Jankovic, J., Hunter, C., Dolimbek, B. Z., Dolimbek, G. S., Adler, C. H., Brashear, A., Comella, C. L., Gordon, M., Riley, D. E., Sethi, K. D., Singer, C., Stacy, M., Tarsy, D., & Atassi, M. Z. (2006). Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia. Neurology, 67(12), 2233-2235. https://doi.org/10.1212/01.wnl.0000249308.66959.43

Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia. / Jankovic, J.; Hunter, C.; Dolimbek, B. Z.; Dolimbek, G. S.; Adler, C. H.; Brashear, A.; Comella, C. L.; Gordon, M.; Riley, D. E.; Sethi, Kapil Dev; Singer, C.; Stacy, M.; Tarsy, D.; Atassi, M. Z.

In: Neurology, Vol. 67, No. 12, 01.12.2006, p. 2233-2235.

Research output: Contribution to journal › Article

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10.1212/01.wnl.0000249308.66959.43