Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China

A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)

Kang Wang, Yu Tuan Wu, Xiang Zhang, Li Chen, Wen Ming Zhu, Ai Jie Zhang, Ke Zheng, Xue Dong Yin, Fan Li, Ling Quan Kong, Bin Lin Ma, Hui Li, Jin Ping Liu, Jun Jiang, Zhu Yue Li, Yang Shi, Guo Sheng Ren, Hong Yuan Li

Research output: Contribution to journalArticle

Abstract

Introduction. Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients. Materials and Methods. 8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified. Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories. Results. For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients. Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01). For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients. An "U" shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed. Conclusion. We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status. An "U" shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.

Original languageEnglish (US)
Article number3692093
JournalBioMed Research International
Volume2019
DOIs
StatePublished - Jan 1 2019

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China
Hazards
Body Mass Index
Breast Neoplasms
Disease-Free Survival
Odds Ratio
Logistics
Tumors
Survival
Logistic Models
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China : A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG). / Wang, Kang; Wu, Yu Tuan; Zhang, Xiang; Chen, Li; Zhu, Wen Ming; Zhang, Ai Jie; Zheng, Ke; Yin, Xue Dong; Li, Fan; Kong, Ling Quan; Ma, Bin Lin; Li, Hui; Liu, Jin Ping; Jiang, Jun; Li, Zhu Yue; Shi, Yang; Ren, Guo Sheng; Li, Hong Yuan.

In: BioMed Research International, Vol. 2019, 3692093, 01.01.2019.

Research output: Contribution to journalArticle

Wang, Kang ; Wu, Yu Tuan ; Zhang, Xiang ; Chen, Li ; Zhu, Wen Ming ; Zhang, Ai Jie ; Zheng, Ke ; Yin, Xue Dong ; Li, Fan ; Kong, Ling Quan ; Ma, Bin Lin ; Li, Hui ; Liu, Jin Ping ; Jiang, Jun ; Li, Zhu Yue ; Shi, Yang ; Ren, Guo Sheng ; Li, Hong Yuan. / Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China : A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG). In: BioMed Research International. 2019 ; Vol. 2019.
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abstract = "Introduction. Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients. Materials and Methods. 8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified. Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories. Results. For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients. Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01). For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients. An {"}U{"} shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed. Conclusion. We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status. An {"}U{"} shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.",
author = "Kang Wang and Wu, {Yu Tuan} and Xiang Zhang and Li Chen and Zhu, {Wen Ming} and Zhang, {Ai Jie} and Ke Zheng and Yin, {Xue Dong} and Fan Li and Kong, {Ling Quan} and Ma, {Bin Lin} and Hui Li and Liu, {Jin Ping} and Jun Jiang and Li, {Zhu Yue} and Yang Shi and Ren, {Guo Sheng} and Li, {Hong Yuan}",
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TY - JOUR

T1 - Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China

T2 - A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)

AU - Wang, Kang

AU - Wu, Yu Tuan

AU - Zhang, Xiang

AU - Chen, Li

AU - Zhu, Wen Ming

AU - Zhang, Ai Jie

AU - Zheng, Ke

AU - Yin, Xue Dong

AU - Li, Fan

AU - Kong, Ling Quan

AU - Ma, Bin Lin

AU - Li, Hui

AU - Liu, Jin Ping

AU - Jiang, Jun

AU - Li, Zhu Yue

AU - Shi, Yang

AU - Ren, Guo Sheng

AU - Li, Hong Yuan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction. Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients. Materials and Methods. 8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified. Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories. Results. For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients. Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01). For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients. An "U" shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed. Conclusion. We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status. An "U" shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.

AB - Introduction. Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients. Materials and Methods. 8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified. Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories. Results. For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients. Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01). For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients. An "U" shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed. Conclusion. We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status. An "U" shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.

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