Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons

William Vaughn McCall, E. H. Ellinwood, J. K. Nishita, T. H. Lee

Research output: Contribution to journalArticle

3 Scopus citations


Intravenous 17-beta-estradiol (BETA) has a potent, stereospecific, and rapid effect on dopamine (DA) neuron firing rate in the substantia nigra compacta (SNC). Our data demonstrate that immediate intravenous pretreatment with the anti-estrogen clomiphene (CLOM) blocks the action of subsequent intravenous BETA administration. Our results provide further physiologic evidence for membrane-bound estradiol (E2) receptors within the rat brain.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
Publication statusPublished - Jan 1 1988
Externally publishedYes


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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