Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome Type 1 (APS1)

Cong Yi Wang, Jing Da Shi, Abdoreza Davoodi-Semiromi, Jin-Xiong She

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The human autoimmune regulator gene (AIRE), responsible for autoimmune polyglandular syndrome Type 1 (APS1), has recently been identified by positional cloning. Here we report the cloning of Aire, the mouse homologue of AIRE, and the characterization of its genomic structure. The complete Aire gene is contained in 14 exons and encodes a protein of 552 amino acids. The coding region shares 77% nucleotide homology and 71% protein homology with human AIRE. As in its human homologue, Aire contains two PHD-type zinc- finger motifs, suggesting that the Aire protein may act as a transcription regulator.

Original languageEnglish (US)
Pages (from-to)322-326
Number of pages5
JournalGenomics
Volume55
Issue number3
DOIs
StatePublished - Feb 1 1999
Externally publishedYes

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Autoimmune Polyendocrinopathies
Regulator Genes
Organism Cloning
Proteins
Zinc Fingers
Exons
Nucleotides
Amino Acids
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome Type 1 (APS1). / Wang, Cong Yi; Shi, Jing Da; Davoodi-Semiromi, Abdoreza; She, Jin-Xiong.

In: Genomics, Vol. 55, No. 3, 01.02.1999, p. 322-326.

Research output: Contribution to journalArticle

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