TY - JOUR
T1 - Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome Type 1 (APS1)
AU - Wang, Cong Yi
AU - Shi, Jing Da
AU - Davoodi-Semiromi, Abdoreza
AU - She, Jin Xiong
PY - 1999/2/1
Y1 - 1999/2/1
N2 - The human autoimmune regulator gene (AIRE), responsible for autoimmune polyglandular syndrome Type 1 (APS1), has recently been identified by positional cloning. Here we report the cloning of Aire, the mouse homologue of AIRE, and the characterization of its genomic structure. The complete Aire gene is contained in 14 exons and encodes a protein of 552 amino acids. The coding region shares 77% nucleotide homology and 71% protein homology with human AIRE. As in its human homologue, Aire contains two PHD-type zinc- finger motifs, suggesting that the Aire protein may act as a transcription regulator.
AB - The human autoimmune regulator gene (AIRE), responsible for autoimmune polyglandular syndrome Type 1 (APS1), has recently been identified by positional cloning. Here we report the cloning of Aire, the mouse homologue of AIRE, and the characterization of its genomic structure. The complete Aire gene is contained in 14 exons and encodes a protein of 552 amino acids. The coding region shares 77% nucleotide homology and 71% protein homology with human AIRE. As in its human homologue, Aire contains two PHD-type zinc- finger motifs, suggesting that the Aire protein may act as a transcription regulator.
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U2 - 10.1006/geno.1998.5656
DO - 10.1006/geno.1998.5656
M3 - Article
C2 - 10049587
AN - SCOPUS:0033082263
SN - 0888-7543
VL - 55
SP - 322
EP - 326
JO - Genomics
JF - Genomics
IS - 3
ER -