Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 α2-8 sialyltransferase

Guichao Zeng, Luoyi Gao, Robert K. Yu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The cDNA coding for GT3-synthase has been cloned from a rat fetal brain cDNA library. The complete nucleotide sequence and the deduced amino acid sequence of the rat GT3-synthase cDNA were highly homologous to those of the mouse GT3-synthase. Quantitative RT-PCR showed that, as a key enzyme for the synthesis of 'c'-series gangliosides, the expression of GT3-synthase was developmentally regulated in embryonic rat brains.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalGene
Volume187
Issue number1
DOIs
StatePublished - Mar 10 1997
Externally publishedYes

Keywords

  • GT3-synthase
  • Gangliosides
  • Gene expression
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Genetics

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