Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22

Terry Roberts, John K. Cowell

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned. This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes from human chromosome 1p22 which are associated with a constitutional chromosome translocation from a patient with stage 4S neuroblastoma, we have identified the human homologue of the Gfi gene and defined a 50 Kb map position within a well characterised YAC contig from the region. The full length cDNA sequence is 81% homologous with the rodent counterparts and, at the protein level, is even more highly conserved.

Original languageEnglish (US)
Pages (from-to)1003-1005
Number of pages3
JournalOncogene
Volume14
Issue number8
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • CDNA sequence
  • Chromosome 1p22
  • Human Gfi gene

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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