Closed-loop stimulation in the control of focal epilepsy of insular origin

Joseph R. Smith, Kostas N. Fountas, Anthony M Murro, Yong D Park, Patrick D. Jenkins, Martha Morrell, Rosanna Esteller, David Greene

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Previous studies have shown that closed-loop or responsive neurostimulation can abort induced or spontaneous epileptiform discharges. Objective: To assess the effectiveness of a programmable cranially implanted closed-loop neurostimulation system in the control of seizures originating from an area relatively inaccessible by open craniotomy. Method: A patient with drug-resistant partial epilepsy had previously undergone open resection of the left frontal opercular cortex and the underlying insular area. Although subdural-depth electrode ictal recordings had been nonlocalizing, depth electrode insular stimulation had produced the patient's habitual aura. Postoperatively, there was a sustained 50% reduction in seizure frequency. The residual seizures were identical to the preoperative seizures. Repeat depth electrode monitoring revealed that the ictal focus was immediately posterior to the previously resected insular area. A closed-loop cranial internal pulse generator system including left anterior insular and posterior orbitofrontal depth electrodes was implanted. Result: There was an additional 60% reduction of seizures. Conclusion: Preliminary observation indicates that responsive neurostimulation may be an effective alternative to higher-risk resective epilepsy surgery.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalStereotactic and Functional Neurosurgery
Volume88
Issue number5
DOIs
StatePublished - Sep 1 2010

Fingerprint

Partial Epilepsy
Seizures
Electrodes
Epilepsy
Stroke
Implanted Electrodes
Craniotomy
Frontal Lobe
Observation

Keywords

  • Depth electrode localization
  • Insular epilepsy
  • Responsive neurostimulator

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Closed-loop stimulation in the control of focal epilepsy of insular origin. / Smith, Joseph R.; Fountas, Kostas N.; Murro, Anthony M; Park, Yong D; Jenkins, Patrick D.; Morrell, Martha; Esteller, Rosanna; Greene, David.

In: Stereotactic and Functional Neurosurgery, Vol. 88, No. 5, 01.09.2010, p. 281-287.

Research output: Contribution to journalArticle

Smith, JR, Fountas, KN, Murro, AM, Park, YD, Jenkins, PD, Morrell, M, Esteller, R & Greene, D 2010, 'Closed-loop stimulation in the control of focal epilepsy of insular origin', Stereotactic and Functional Neurosurgery, vol. 88, no. 5, pp. 281-287. https://doi.org/10.1159/000316760
Smith, Joseph R. ; Fountas, Kostas N. ; Murro, Anthony M ; Park, Yong D ; Jenkins, Patrick D. ; Morrell, Martha ; Esteller, Rosanna ; Greene, David. / Closed-loop stimulation in the control of focal epilepsy of insular origin. In: Stereotactic and Functional Neurosurgery. 2010 ; Vol. 88, No. 5. pp. 281-287.
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