Coccidioidomycosis in pregnancy: Case report and literature review of associated placental lesions

Heloise Labuschagne, C. Burns, Stacy Martinez, Maira Carrillo, Melissa Waggoner, Irene Schwanninger, James Maher, Moss Hampton, Javier Flores-Guardado, Natalia E. Schlabritz-Loutsevitch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background Coccidioidomycosis is an endemic fungal infection found most commonly in the Southwestern United States, Northwestern Mexico, and parts of Central and South America. Although infection is relatively uncommon during pregnancy, it is imperative to have an index of suspicion in order to diagnose and begin timely treatment to prevent dissemination and dire consequences. Case report A 33-year-old Hispanic female was evaluated after she was involved in an automobile accident. Radiographic evaluation showed a 3.2 × 3.2 cm cavitary thick-walled lesion. A biopsy was negative for malignancy. Evaluation was positive for coccidioidomycosis by complement fixation reaction. Four months later, the patient presented 7 weeks into a pregnancy with massive hemoptysis. Bronchoscopy revealed bleeding from the right upper lobe and emergency embolization was performed. The patient had a spontaneous abortion 9 days after admission. The right upper and middle lobes of the lung were resected due to continuous bleeding. A subsequent pregnancy was un-eventful. Coccidioidomycosis titers remained negative throughout the second pregnancy. Discussion This case demonstrates the potential for severe pulmonary coccidioidomycosis and vascular strain of pregnancy-associated vascular expansion in the first trimester of pregnancy and the possibility of a favorable pregnancy outcome in subsequent pregnancies after appropriate treatment. The route of feto-maternal transmission and placental lesions in coccidioidomycosis are discussed.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalCase Reports in Women's Health
StatePublished - Oct 1 2016
Externally publishedYes


  • Coccidioidomycosis
  • Placental lesions
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Coccidioidomycosis in pregnancy: Case report and literature review of associated placental lesions'. Together they form a unique fingerprint.

Cite this