Cognition enhancement strategies

James A. Bibb, Mark R. Mayford, Joseph Zhuo Tsien, Cristina M. Alberini

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Many mental disorders and neurodegenerative and neurodevelopmental diseases involve cognitive deficits. Remarkable advances and new technologies are providing a clearer picture of the molecular basis of cognition. In conjunction with an SFN2010 symposium, we provided here a brief overview of the molecular mechanisms of cognition, with emphasis on the development of treatments for cognitive disorders. Activity-dependent changes in gene expression and protein synthesis integrate with synapse selection to form memory circuits. A neuronal activity-dependent molecular tagging system that uses the gene expression program to record memory circuit formation represents one new tool to study cognition. Regulation of protein translation, protein degradation, cytoskeletal dynamics, extracellular matrix interactions, second messenger signaling, and neurotransmitter receptor trafficking and function are all components of synaptic remodeling essential for cognition. Selective targeting of specific effectors in these processes, such as NMDA receptors, may serve as an effective strategy to treat cognitive deficits.

Original languageEnglish (US)
Pages (from-to)14987-14992
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number45
DOIs
StatePublished - Nov 10 2010

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Cognition
Gene Expression
Neurotransmitter Receptor
Protein Biosynthesis
Second Messenger Systems
N-Methyl-D-Aspartate Receptors
Mental Disorders
Neurodegenerative Diseases
Synapses
Proteolysis
Extracellular Matrix
Technology
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bibb, J. A., Mayford, M. R., Tsien, J. Z., & Alberini, C. M. (2010). Cognition enhancement strategies. Journal of Neuroscience, 30(45), 14987-14992. https://doi.org/10.1523/JNEUROSCI.4419-10.2010

Cognition enhancement strategies. / Bibb, James A.; Mayford, Mark R.; Tsien, Joseph Zhuo; Alberini, Cristina M.

In: Journal of Neuroscience, Vol. 30, No. 45, 10.11.2010, p. 14987-14992.

Research output: Contribution to journalArticle

Bibb, JA, Mayford, MR, Tsien, JZ & Alberini, CM 2010, 'Cognition enhancement strategies', Journal of Neuroscience, vol. 30, no. 45, pp. 14987-14992. https://doi.org/10.1523/JNEUROSCI.4419-10.2010
Bibb, James A. ; Mayford, Mark R. ; Tsien, Joseph Zhuo ; Alberini, Cristina M. / Cognition enhancement strategies. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 45. pp. 14987-14992.
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