Cognition enhancement strategies

James A. Bibb, Mark R. Mayford, Joe Z. Tsien, Cristina M. Alberini

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Many mental disorders and neurodegenerative and neurodevelopmental diseases involve cognitive deficits. Remarkable advances and new technologies are providing a clearer picture of the molecular basis of cognition. In conjunction with an SFN2010 symposium, we provided here a brief overview of the molecular mechanisms of cognition, with emphasis on the development of treatments for cognitive disorders. Activity-dependent changes in gene expression and protein synthesis integrate with synapse selection to form memory circuits. A neuronal activity-dependent molecular tagging system that uses the gene expression program to record memory circuit formation represents one new tool to study cognition. Regulation of protein translation, protein degradation, cytoskeletal dynamics, extracellular matrix interactions, second messenger signaling, and neurotransmitter receptor trafficking and function are all components of synaptic remodeling essential for cognition. Selective targeting of specific effectors in these processes, such as NMDA receptors, may serve as an effective strategy to treat cognitive deficits.

Original languageEnglish (US)
Pages (from-to)14987-14992
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number45
DOIs
Publication statusPublished - Nov 10 2010

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ASJC Scopus subject areas

  • Neuroscience(all)

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Bibb, J. A., Mayford, M. R., Tsien, J. Z., & Alberini, C. M. (2010). Cognition enhancement strategies. Journal of Neuroscience, 30(45), 14987-14992. https://doi.org/10.1523/JNEUROSCI.4419-10.2010