Cognitive status of children treated with central nervous system prophylactic chemotherapy for acute lymphocytic leukemia

Ronald T. Brown, Avi Madan-Swain, Ray Pais, Richard G. Lambert, Kevin Baldwin, Robert Casey, Natalie Frank, Sandra Griffin Bishop Sexson, Abdel Ragab, Randy W. Kamphaus

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Treatment-related cognitive impairments have been reported for survivors of childhood leukemia following prophylactic central nervous system (CNS) treatment with craniospinal radiation. We examined the neurocognitive status of 46 children with acute lymphocytic leukemia (ALL) to assess the impact of a regimen consisting of systemic chemotherapy and prophylactic CNS chemotherapy. By comparing three groups of ALL children (i.e., patients whose diagnosis was recent, patients 1 year postdiagnosis currently receiving CNS prophylactic chemotherapy, and offtherapy patients who had been treated with chemotherapy for 3 years) and their healthy siblings on measures of sequential and simultaneous processing, we were able to examine the effects of CNS prophylactic and systemic chemotherapy at various points during treatment. Results indicate that the children who had received a 3-year course of chemotherapy (off-therapy patients) were more impaired on tasks involving right-hemisphere simultaneous processing than were sibling controls or ALL children whose diagnosis was recent and whose treatment had just begun. Age at diagnosis did not interact with the effects of chemotherapy. These findings support the need for continued evaluation of cognitive functioning in ALL, children receiving CNS prophylactic chemotherapy to identify potential harmful neurocognitive sequelae of treatment.

Original languageEnglish (US)
Pages (from-to)481-497
Number of pages17
JournalArchives of Clinical Neuropsychology
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Central Nervous System
Drug Therapy
Siblings
Therapeutics
Survivors
Leukemia
Radiation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Cognitive status of children treated with central nervous system prophylactic chemotherapy for acute lymphocytic leukemia. / Brown, Ronald T.; Madan-Swain, Avi; Pais, Ray; Lambert, Richard G.; Baldwin, Kevin; Casey, Robert; Frank, Natalie; Sexson, Sandra Griffin Bishop; Ragab, Abdel; Kamphaus, Randy W.

In: Archives of Clinical Neuropsychology, Vol. 7, No. 6, 01.01.1992, p. 481-497.

Research output: Contribution to journalArticle

Brown, RT, Madan-Swain, A, Pais, R, Lambert, RG, Baldwin, K, Casey, R, Frank, N, Sexson, SGB, Ragab, A & Kamphaus, RW 1992, 'Cognitive status of children treated with central nervous system prophylactic chemotherapy for acute lymphocytic leukemia', Archives of Clinical Neuropsychology, vol. 7, no. 6, pp. 481-497. https://doi.org/10.1016/0887-6177(92)90138-D
Brown, Ronald T. ; Madan-Swain, Avi ; Pais, Ray ; Lambert, Richard G. ; Baldwin, Kevin ; Casey, Robert ; Frank, Natalie ; Sexson, Sandra Griffin Bishop ; Ragab, Abdel ; Kamphaus, Randy W. / Cognitive status of children treated with central nervous system prophylactic chemotherapy for acute lymphocytic leukemia. In: Archives of Clinical Neuropsychology. 1992 ; Vol. 7, No. 6. pp. 481-497.
@article{8de0e783bedf40f49212c3e36f4e00bb,
title = "Cognitive status of children treated with central nervous system prophylactic chemotherapy for acute lymphocytic leukemia",
abstract = "Treatment-related cognitive impairments have been reported for survivors of childhood leukemia following prophylactic central nervous system (CNS) treatment with craniospinal radiation. We examined the neurocognitive status of 46 children with acute lymphocytic leukemia (ALL) to assess the impact of a regimen consisting of systemic chemotherapy and prophylactic CNS chemotherapy. By comparing three groups of ALL children (i.e., patients whose diagnosis was recent, patients 1 year postdiagnosis currently receiving CNS prophylactic chemotherapy, and offtherapy patients who had been treated with chemotherapy for 3 years) and their healthy siblings on measures of sequential and simultaneous processing, we were able to examine the effects of CNS prophylactic and systemic chemotherapy at various points during treatment. Results indicate that the children who had received a 3-year course of chemotherapy (off-therapy patients) were more impaired on tasks involving right-hemisphere simultaneous processing than were sibling controls or ALL children whose diagnosis was recent and whose treatment had just begun. Age at diagnosis did not interact with the effects of chemotherapy. These findings support the need for continued evaluation of cognitive functioning in ALL, children receiving CNS prophylactic chemotherapy to identify potential harmful neurocognitive sequelae of treatment.",
author = "Brown, {Ronald T.} and Avi Madan-Swain and Ray Pais and Lambert, {Richard G.} and Kevin Baldwin and Robert Casey and Natalie Frank and Sexson, {Sandra Griffin Bishop} and Abdel Ragab and Kamphaus, {Randy W.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0887-6177(92)90138-D",
language = "English (US)",
volume = "7",
pages = "481--497",
journal = "Archives of Clinical Neuropsychology",
issn = "0887-6177",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Cognitive status of children treated with central nervous system prophylactic chemotherapy for acute lymphocytic leukemia

AU - Brown, Ronald T.

AU - Madan-Swain, Avi

AU - Pais, Ray

AU - Lambert, Richard G.

AU - Baldwin, Kevin

AU - Casey, Robert

AU - Frank, Natalie

AU - Sexson, Sandra Griffin Bishop

AU - Ragab, Abdel

AU - Kamphaus, Randy W.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Treatment-related cognitive impairments have been reported for survivors of childhood leukemia following prophylactic central nervous system (CNS) treatment with craniospinal radiation. We examined the neurocognitive status of 46 children with acute lymphocytic leukemia (ALL) to assess the impact of a regimen consisting of systemic chemotherapy and prophylactic CNS chemotherapy. By comparing three groups of ALL children (i.e., patients whose diagnosis was recent, patients 1 year postdiagnosis currently receiving CNS prophylactic chemotherapy, and offtherapy patients who had been treated with chemotherapy for 3 years) and their healthy siblings on measures of sequential and simultaneous processing, we were able to examine the effects of CNS prophylactic and systemic chemotherapy at various points during treatment. Results indicate that the children who had received a 3-year course of chemotherapy (off-therapy patients) were more impaired on tasks involving right-hemisphere simultaneous processing than were sibling controls or ALL children whose diagnosis was recent and whose treatment had just begun. Age at diagnosis did not interact with the effects of chemotherapy. These findings support the need for continued evaluation of cognitive functioning in ALL, children receiving CNS prophylactic chemotherapy to identify potential harmful neurocognitive sequelae of treatment.

AB - Treatment-related cognitive impairments have been reported for survivors of childhood leukemia following prophylactic central nervous system (CNS) treatment with craniospinal radiation. We examined the neurocognitive status of 46 children with acute lymphocytic leukemia (ALL) to assess the impact of a regimen consisting of systemic chemotherapy and prophylactic CNS chemotherapy. By comparing three groups of ALL children (i.e., patients whose diagnosis was recent, patients 1 year postdiagnosis currently receiving CNS prophylactic chemotherapy, and offtherapy patients who had been treated with chemotherapy for 3 years) and their healthy siblings on measures of sequential and simultaneous processing, we were able to examine the effects of CNS prophylactic and systemic chemotherapy at various points during treatment. Results indicate that the children who had received a 3-year course of chemotherapy (off-therapy patients) were more impaired on tasks involving right-hemisphere simultaneous processing than were sibling controls or ALL children whose diagnosis was recent and whose treatment had just begun. Age at diagnosis did not interact with the effects of chemotherapy. These findings support the need for continued evaluation of cognitive functioning in ALL, children receiving CNS prophylactic chemotherapy to identify potential harmful neurocognitive sequelae of treatment.

UR - http://www.scopus.com/inward/record.url?scp=0026785997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026785997&partnerID=8YFLogxK

U2 - 10.1016/0887-6177(92)90138-D

DO - 10.1016/0887-6177(92)90138-D

M3 - Article

VL - 7

SP - 481

EP - 497

JO - Archives of Clinical Neuropsychology

JF - Archives of Clinical Neuropsychology

SN - 0887-6177

IS - 6

ER -