Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence

Michael Y. Wong, Ozgur H. Harmanli, Mehmet Agar, Vani Dandolu, M. H.Terry Grody, Michael Peter Diamond

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

OBJECTIVE: Reduction in the collagen content of the pelvic floor tissue of the patients with pelvic organ prolapse and/or stress urinary incontinence has been documented previously. However, this is less clear for nonsupport tissue. We aimed to compare the collagen content of the uterine cervix, a nonsupport tissue, of women who had pelvic organ prolapse with and without stress urinary incontinence against those without these problems. STUDY DESIGN: Cervical collagen content was compared between 14 women who had pelvic organ prolapse with and without stress urinary incontinence and 17 controls without these conditions. Specimens were obtained after surgery for benign gynecologic conditions. RESULTS: Groups were similar with respect to age, parity, body mass index, and tobacco use. Women who had pelvic organ prolapse with and without stress urinary incontinence possessed significantly less collagen compared with the controls (8.10% ± 3.43% vs 12.35% ± 4.72%, P = .0104). Furthermore age, parity, body mass index, or tobacco use had no significant relationship to collagen content. CONCLUSION: Cervical collagen content is significantly decreased in women who have pelvic organ prolapse with and without stress urinary incontinence regardless of age, parity, body mass index, or tobacco use.

Original languageEnglish (US)
Pages (from-to)1597-1599
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume189
Issue number6
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Pelvic Organ Prolapse
Stress Urinary Incontinence
Collagen
Tobacco Use
Parity
Body Mass Index
Gynecologic Surgical Procedures
Pelvic Floor
Cervix Uteri

Keywords

  • Collagen content
  • Pelvic organ prolapse
  • Stress urinary incontinence
  • Uterine cervix

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence. / Wong, Michael Y.; Harmanli, Ozgur H.; Agar, Mehmet; Dandolu, Vani; Grody, M. H.Terry; Diamond, Michael Peter.

In: American Journal of Obstetrics and Gynecology, Vol. 189, No. 6, 01.01.2003, p. 1597-1599.

Research output: Contribution to journalArticle

Wong, Michael Y. ; Harmanli, Ozgur H. ; Agar, Mehmet ; Dandolu, Vani ; Grody, M. H.Terry ; Diamond, Michael Peter. / Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence. In: American Journal of Obstetrics and Gynecology. 2003 ; Vol. 189, No. 6. pp. 1597-1599.
@article{f5bf2b3ca3574cb28985ba31ed27d6be,
title = "Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence",
abstract = "OBJECTIVE: Reduction in the collagen content of the pelvic floor tissue of the patients with pelvic organ prolapse and/or stress urinary incontinence has been documented previously. However, this is less clear for nonsupport tissue. We aimed to compare the collagen content of the uterine cervix, a nonsupport tissue, of women who had pelvic organ prolapse with and without stress urinary incontinence against those without these problems. STUDY DESIGN: Cervical collagen content was compared between 14 women who had pelvic organ prolapse with and without stress urinary incontinence and 17 controls without these conditions. Specimens were obtained after surgery for benign gynecologic conditions. RESULTS: Groups were similar with respect to age, parity, body mass index, and tobacco use. Women who had pelvic organ prolapse with and without stress urinary incontinence possessed significantly less collagen compared with the controls (8.10{\%} ± 3.43{\%} vs 12.35{\%} ± 4.72{\%}, P = .0104). Furthermore age, parity, body mass index, or tobacco use had no significant relationship to collagen content. CONCLUSION: Cervical collagen content is significantly decreased in women who have pelvic organ prolapse with and without stress urinary incontinence regardless of age, parity, body mass index, or tobacco use.",
keywords = "Collagen content, Pelvic organ prolapse, Stress urinary incontinence, Uterine cervix",
author = "Wong, {Michael Y.} and Harmanli, {Ozgur H.} and Mehmet Agar and Vani Dandolu and Grody, {M. H.Terry} and Diamond, {Michael Peter}",
year = "2003",
month = "1",
day = "1",
doi = "10.1016/j.ajog.2003.09.043",
language = "English (US)",
volume = "189",
pages = "1597--1599",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence

AU - Wong, Michael Y.

AU - Harmanli, Ozgur H.

AU - Agar, Mehmet

AU - Dandolu, Vani

AU - Grody, M. H.Terry

AU - Diamond, Michael Peter

PY - 2003/1/1

Y1 - 2003/1/1

N2 - OBJECTIVE: Reduction in the collagen content of the pelvic floor tissue of the patients with pelvic organ prolapse and/or stress urinary incontinence has been documented previously. However, this is less clear for nonsupport tissue. We aimed to compare the collagen content of the uterine cervix, a nonsupport tissue, of women who had pelvic organ prolapse with and without stress urinary incontinence against those without these problems. STUDY DESIGN: Cervical collagen content was compared between 14 women who had pelvic organ prolapse with and without stress urinary incontinence and 17 controls without these conditions. Specimens were obtained after surgery for benign gynecologic conditions. RESULTS: Groups were similar with respect to age, parity, body mass index, and tobacco use. Women who had pelvic organ prolapse with and without stress urinary incontinence possessed significantly less collagen compared with the controls (8.10% ± 3.43% vs 12.35% ± 4.72%, P = .0104). Furthermore age, parity, body mass index, or tobacco use had no significant relationship to collagen content. CONCLUSION: Cervical collagen content is significantly decreased in women who have pelvic organ prolapse with and without stress urinary incontinence regardless of age, parity, body mass index, or tobacco use.

AB - OBJECTIVE: Reduction in the collagen content of the pelvic floor tissue of the patients with pelvic organ prolapse and/or stress urinary incontinence has been documented previously. However, this is less clear for nonsupport tissue. We aimed to compare the collagen content of the uterine cervix, a nonsupport tissue, of women who had pelvic organ prolapse with and without stress urinary incontinence against those without these problems. STUDY DESIGN: Cervical collagen content was compared between 14 women who had pelvic organ prolapse with and without stress urinary incontinence and 17 controls without these conditions. Specimens were obtained after surgery for benign gynecologic conditions. RESULTS: Groups were similar with respect to age, parity, body mass index, and tobacco use. Women who had pelvic organ prolapse with and without stress urinary incontinence possessed significantly less collagen compared with the controls (8.10% ± 3.43% vs 12.35% ± 4.72%, P = .0104). Furthermore age, parity, body mass index, or tobacco use had no significant relationship to collagen content. CONCLUSION: Cervical collagen content is significantly decreased in women who have pelvic organ prolapse with and without stress urinary incontinence regardless of age, parity, body mass index, or tobacco use.

KW - Collagen content

KW - Pelvic organ prolapse

KW - Stress urinary incontinence

KW - Uterine cervix

UR - http://www.scopus.com/inward/record.url?scp=0347357752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347357752&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2003.09.043

DO - 10.1016/j.ajog.2003.09.043

M3 - Article

C2 - 14710077

AN - SCOPUS:0347357752

VL - 189

SP - 1597

EP - 1599

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -