Collapsing glomerulopathy with rare associated coxsackie virus infection

A case report

Xuejing Zhu, Hong Liu, Shuguang Yuan, Xiangqing Xu, Zheng Dong, Fuyou Liu

Research output: Contribution to journalArticle

Abstract

A 38-year-old Chinese man was admitted to the Second Xiangya Hospital of the Central South University (Changsha, China) with heavy proteinuria and rapidly progressing renal failure with nephrotic syndrome. An initial renal biopsy identified collapsing glomerulopathy (CG) with characteristic segmental collapse of the glomerular tuft and marked hypertrophy and hyperplasia of the visceral epithelial cells. A second renal biopsy showed dilation of glomerular capillary loops as a result of effective treatment with rapamycin and anti-viral therapy. Serology for the coxsackie virus antibody was positive when the collapsing lesion was present, and became negative following treatment, which indicated a strong association between the development of CG and coxsackie virus infection. To the best of our knowledge, this is the first case report of CG associated with coxsackie virus infection.

Original languageEnglish (US)
Pages (from-to)1871-1874
Number of pages4
JournalExperimental and Therapeutic Medicine
Volume11
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

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Coxsackievirus Infections
Satellite Viruses
Kidney
Biopsy
Enterovirus
Nephrotic Syndrome
Sirolimus
Serology
Proteinuria
Hypertrophy
Hyperplasia
Renal Insufficiency
Dilatation
China
Therapeutics
Epithelial Cells
Antibodies

Keywords

  • Collapsing glomerulopathy
  • Coxsackie virus
  • Renal biopsy

ASJC Scopus subject areas

  • Immunology and Microbiology (miscellaneous)
  • Cancer Research

Cite this

Collapsing glomerulopathy with rare associated coxsackie virus infection : A case report. / Zhu, Xuejing; Liu, Hong; Yuan, Shuguang; Xu, Xiangqing; Dong, Zheng; Liu, Fuyou.

In: Experimental and Therapeutic Medicine, Vol. 11, No. 5, 01.05.2016, p. 1871-1874.

Research output: Contribution to journalArticle

Zhu, Xuejing ; Liu, Hong ; Yuan, Shuguang ; Xu, Xiangqing ; Dong, Zheng ; Liu, Fuyou. / Collapsing glomerulopathy with rare associated coxsackie virus infection : A case report. In: Experimental and Therapeutic Medicine. 2016 ; Vol. 11, No. 5. pp. 1871-1874.
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