Colposcopy quality control by remote review of digitized colposcopic images

Daron Gale Ferris, Mark S. Litaker

Research output: Contribution to journalArticle

18 Scopus citations


This study was undertaken to estimate the accuracy of colposcopy quality control review of subjects' digitized colposcopic images during the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion triage study (ALTS). After colposcopic examination and the acquisition of 2 digitized cervical images, colposcopists recorded colposcopic diagnoses in a standardized computer database. The images were transferred by modem to colposcopy quality control reviewers for a blinded interpretation, including assessment of image quality. Reviewers' and colposcopists' diagnoses were compared with histologic diagnoses using standard contingency table methods. Colposcopists and reviewers underdiagnosed 16.1% and 25.3% of subjects, and overdiagnosed 44.7% and 19.8% of subjects compared with histology, respectively. The sensitivity and specificity for detecting cervical intraepithelial neoplasia 2 or greater were 35.4% versus 23.2%, P <. 0001, and 89.9% versus 95.0%, P <. 0001, respectively, for colposcopists and reviewers. Colposcopy quality control by review of digitized colposcopic images in clinical trials warrants further evaluation if the accuracy can be improved.

Original languageEnglish (US)
Pages (from-to)1934-1941
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Jan 1 2004


  • ATLS trial
  • Cervical intraepithelial neoplasia
  • Colposcopy
  • Quality control

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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