Combination clomiphene citrate/human menopausal gonadotropin stimulation protocols for in vitro fertilization-embryo transfer

George A. Hill, Michael Peter Diamond, Wayne S. Maxson, Carl M. Herbert, Bobby W. Webster, William K. Vaughn, Kevin G. Osteen, B. Jane Rogers, Anne Colston Wentz

Research output: Contribution to journalArticle

4 Scopus citations


Various protocols have been utilized for stimulation of multiple ovarian follicles in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). Previous studies have suggested that the combination of clomiphene citrate (CC) and human menopausal gonadotropins (hMG) is superior to either CC or hMG alone in terms of follicular development, oocyte recovery, and embryo transfer. However, no significant increase in viable pregnancy rates has been reported with any of the protocols. This report examines five different CC/hMG protocols. While differences were seen in terms of serum estradiol response and fertilization rates of mature oocytes among the various protocols, no significant differences were found in terms of follicular development, oocyte recovery, embryo transfer, or pregnancy. The pregnancy rate in IVF-ET appears unaffected by variations in the dose and timing of CC and hMG in a combination protocol.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalJournal of In Vitro Fertilization and Embryo Transfer
Issue number1
Publication statusPublished - Feb 1 1987
Externally publishedYes



  • clomiphene citrate
  • human menopausal gonadotropins
  • in vitro fertilization-embryo transfer
  • ovarian hyperstimulation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Obstetrics and Gynecology
  • Developmental Biology

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