Combined abuse of clonidine and amitriptyline in a patient on buprenorphine maintenance treatment

J. Paul Seale, Trent Dittmer, Erika J. Sigman, Holly Clemons, J. Aaron Johnson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Buprenorphine/naloxone maintenance therapy is often prescribed in primary care to treat opioid dependence. Previous reports have described concomitant abuse of opioids and clonidine. In this case, a primary care patient on buprenorphine/naloxone maintenance therapy demonstrating alteredmental status, hallucinations, falls, and rebound hypertension was found to be concomitantly abusing clonidine and amitryptyline, which share metabolic pathways with buprenorphine. Clinicians should be aware of patients' combining amitryptyline, clonidine, and gabapentin with buprenorphine to achieve a mood altering state, avoid co-prescribing them if possible, and maintain communication with pharmacies and other providers when they are prescribed.

Original languageEnglish (US)
Pages (from-to)476-478
Number of pages3
JournalJournal of Addiction Medicine
Volume8
Issue number6
DOIs
StatePublished - Nov 1 2014

Fingerprint

Buprenorphine
Amitriptyline
Clonidine
Opioid Analgesics
Primary Health Care
Pharmacies
Hallucinations
Metabolic Networks and Pathways
Therapeutics
Communication
Hypertension
Naloxone Drug Combination Buprenorphine

Keywords

  • Antidepressive agents
  • Buprenorphine [MeSH]
  • Clonidine
  • Naloxone
  • Receptors opioid [MeSH]
  • Tricyclic

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Combined abuse of clonidine and amitriptyline in a patient on buprenorphine maintenance treatment. / Seale, J. Paul; Dittmer, Trent; Sigman, Erika J.; Clemons, Holly; Johnson, J. Aaron.

In: Journal of Addiction Medicine, Vol. 8, No. 6, 01.11.2014, p. 476-478.

Research output: Contribution to journalArticle

Seale, J. Paul ; Dittmer, Trent ; Sigman, Erika J. ; Clemons, Holly ; Johnson, J. Aaron. / Combined abuse of clonidine and amitriptyline in a patient on buprenorphine maintenance treatment. In: Journal of Addiction Medicine. 2014 ; Vol. 8, No. 6. pp. 476-478.
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