Combining physical and biologic parameters to predict radiation-induced lung toxicity in patients with non-small-cell lung cancer treated with definitive radiation therapy

Matthew H. Stenmark, Xu Wei Cai, Kerby Shedden, James A. Hayman, Shuanghu Yuan, Timothy Ritter, Randall K. Ten Haken, Theodore S. Lawrence, Feng Ming Kong

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Purpose: To investigate the plasma dynamics of 5 proinflammatory/fibrogenic cytokines, including interleukin-1beta (IL-1β), IL-6, IL-8, tumor necrosis factor alpha (TNF-α), and transforming growth factor beta1 (TGF-β1) to ascertain their value in predicting radiation-induced lung toxicity (RILT), both individually and in combination with physical dosimetric parameters. Methods and Materials: Treatments of patients receiving definitive conventionally fractionated radiation therapy (RT) on clinical trial for inoperable stages I-III lung cancer were prospectively evaluated. Circulating cytokine levels were measured prior to and at weeks 2 and 4 during RT. The primary endpoint was symptomatic RILT, defined as grade 2 and higher radiation pneumonitis or symptomatic pulmonary fibrosis. Minimum follow-up was 18 months. Results: Of 58 eligible patients, 10 (17.2%) patients developed RILT. Lower pretreatment IL-8 levels were significantly correlated with development of RILT, while radiation-induced elevations of TGF-ß1 were weakly correlated with RILT. Significant correlations were not found for any of the remaining 3 cytokines or for any clinical or dosimetric parameters. Using receiver operator characteristic curves for predictive risk assessment modeling, we found both individual cytokines and dosimetric parameters were poor independent predictors of RILT. However, combining IL-8, TGF-ß1, and mean lung dose into a single model yielded an improved predictive ability (P<.001) compared to either variable alone. Conclusions: Combining inflammatory cytokines with physical dosimetric factors may provide a more accurate model for RILT prediction. Future study with a larger number of cases and events is needed to validate such findings.

Original languageEnglish (US)
Pages (from-to)e217-e222
JournalInternational Journal of Radiation Oncology Biology Physics
Volume84
Issue number2
DOIs
StatePublished - Oct 1 2012

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Non-Small Cell Lung Carcinoma
toxicity
lungs
radiation therapy
Radiotherapy
cancer
Radiation
Lung
radiation
Transforming Growth Factor beta1
Cytokines
Interleukin-8
Radiation Pneumonitis
interleukins
physical factors
Pulmonary Fibrosis
fibrosis
plasma dynamics
risk assessment
necrosis

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Combining physical and biologic parameters to predict radiation-induced lung toxicity in patients with non-small-cell lung cancer treated with definitive radiation therapy. / Stenmark, Matthew H.; Cai, Xu Wei; Shedden, Kerby; Hayman, James A.; Yuan, Shuanghu; Ritter, Timothy; Ten Haken, Randall K.; Lawrence, Theodore S.; Kong, Feng Ming.

In: International Journal of Radiation Oncology Biology Physics, Vol. 84, No. 2, 01.10.2012, p. e217-e222.

Research output: Contribution to journalArticle

Stenmark, Matthew H. ; Cai, Xu Wei ; Shedden, Kerby ; Hayman, James A. ; Yuan, Shuanghu ; Ritter, Timothy ; Ten Haken, Randall K. ; Lawrence, Theodore S. ; Kong, Feng Ming. / Combining physical and biologic parameters to predict radiation-induced lung toxicity in patients with non-small-cell lung cancer treated with definitive radiation therapy. In: International Journal of Radiation Oncology Biology Physics. 2012 ; Vol. 84, No. 2. pp. e217-e222.
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AU - Cai, Xu Wei

AU - Shedden, Kerby

AU - Hayman, James A.

AU - Yuan, Shuanghu

AU - Ritter, Timothy

AU - Ten Haken, Randall K.

AU - Lawrence, Theodore S.

AU - Kong, Feng Ming

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