Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome

Jack J.H. Bleesing, John Edward Janik, Thomas A. Fleisher

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Patients with T-cell large granular lymphocyte (T-LGL) leukaemia and autoimmune lymphoproliferative syndrome (ALPS) share many features, including autoimmunity and an expansion of (cytotoxic) T cells, which in ALPS patients express an unusual (B220) isoform of CD45, corresponding to an altered O-glycosylation profile. Here we showed that T-LGL leukaemia cells also expressed this B220 isoform. We hypothesize that B220+ T cells constitute proliferating T cells that have become competent to undergo apoptosis, but that constitutive (ALPS) or functional (T-LGL) defects prevent this process. Altered O-glycosylation of the extracellular domains of CD45 may have consequences for this tyrosine phosphatase as a regulator of cell proliferation and survival.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number1
DOIs
StatePublished - Jan 16 2003

Keywords

  • Apoptosis
  • Autoimmune lymphoproliferative syndrome
  • CD45 isoforms
  • Glycosylation
  • T-LGL leukaemia

ASJC Scopus subject areas

  • Hematology

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