TY - JOUR
T1 - Common genes contribute to depressive symptoms and heart rate variability
T2 - The twins heart study
AU - Su, Shaoyong
AU - Lampert, Rachel
AU - Lee, Forrester
AU - Bremner, J. Douglas
AU - Snieder, Harold
AU - Jones, Linda
AU - Murrah, Nancy V.
AU - Goldberg, Jack
AU - Vaccarino, Viola
N1 - Funding Information:
This study was supported by K24HL077506, R01 HL68630 and R01 AG026255 from the National Institutes of Health; by the Emory University General Clinical Research Center MO1-RR00039 and by grant 0245115N and 0725513B from the American Heart Association.
PY - 2010/2
Y1 - 2010/2
N2 - Depression and reduced heart rate variability (HRV) are predictors of coronary artery disease (CAD), and highly correlated with each other. However, little is known to what extend this correlation can be explained by common genetic components. We examined 198 middle-aged male twins (121 monozygotic and 77 dizygotic) from the Vietnam Era Twin Registry. Current depressive symptoms were assessed using the Beck Depression Inventory-II and HRV was assessed on 24-hour electrocardiographic Holter recordings. Five frequency domain variables were used, including ultra low frequency (ULF), very low frequency (VLF), low frequency (LF), high frequency (HF) and total power (TPow). Structural equation modeling was used to estimate shared genetic effects for depressive symptoms and the HRV frequency domains. Both depressive symptoms (h2=.5) and all measurements of HRV showed high heritability (h2=.43-.63). A significant inverse correlation was found between depressive symptoms and all HRV indices except LF and HF, with the highest coefficient (r) for TPow (r = -.24, P = .01) and ULF (r = -.24, P = .01). Bivariate genetic modeling revealed significant genetic correlations between depressive symptoms and TPow (r A = -.21, P = .04), as well as ULF (rA = -.23, P = .02). Of the total covariance between depressive symptoms and these two HRV indices, over 80% was due to the same genetic factors. In conclusion, depressive symptoms are associated with decreased HRV and this association is due, in large part, to a shared genetic effect. These results suggest that a common neurobiological dysfunction links depression and autonomic dysregulation.
AB - Depression and reduced heart rate variability (HRV) are predictors of coronary artery disease (CAD), and highly correlated with each other. However, little is known to what extend this correlation can be explained by common genetic components. We examined 198 middle-aged male twins (121 monozygotic and 77 dizygotic) from the Vietnam Era Twin Registry. Current depressive symptoms were assessed using the Beck Depression Inventory-II and HRV was assessed on 24-hour electrocardiographic Holter recordings. Five frequency domain variables were used, including ultra low frequency (ULF), very low frequency (VLF), low frequency (LF), high frequency (HF) and total power (TPow). Structural equation modeling was used to estimate shared genetic effects for depressive symptoms and the HRV frequency domains. Both depressive symptoms (h2=.5) and all measurements of HRV showed high heritability (h2=.43-.63). A significant inverse correlation was found between depressive symptoms and all HRV indices except LF and HF, with the highest coefficient (r) for TPow (r = -.24, P = .01) and ULF (r = -.24, P = .01). Bivariate genetic modeling revealed significant genetic correlations between depressive symptoms and TPow (r A = -.21, P = .04), as well as ULF (rA = -.23, P = .02). Of the total covariance between depressive symptoms and these two HRV indices, over 80% was due to the same genetic factors. In conclusion, depressive symptoms are associated with decreased HRV and this association is due, in large part, to a shared genetic effect. These results suggest that a common neurobiological dysfunction links depression and autonomic dysregulation.
KW - Common genes
KW - Depressive symptoms
KW - Heart rate variability
KW - Twin study
UR - http://www.scopus.com/inward/record.url?scp=77953243618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953243618&partnerID=8YFLogxK
U2 - 10.1375/twin.13.1.1
DO - 10.1375/twin.13.1.1
M3 - Article
C2 - 20158303
AN - SCOPUS:77953243618
SN - 1832-4274
VL - 13
SP - 1
EP - 9
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 1
ER -