Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins

Y. Jamshidi, H. Snieder, Xiaoling Wang, T. D. Spector, N. D. Carter, S. D. O'Dell

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aims/hypothesis: Inhibition of signal transduction by suppressor of cytokine signalling-3 (SOCS-3) potentially influences resistance to insulin and leptin. The aim of this study was to test the association between three single-nucleotide polymorphisms (SNPs) representative of common linkage disequilibrium clusters in SOCS3 (rs4969169, rs12953258 and rs8064821) and obesity measures, insulin sensitivity measures and serum lipids in the general population. Methods: The three SNPs, which had rare allele frequencies >0.06, were genotyped in 2,777 female twins of European extraction (mean age 47.4±12.5 years) from the St Thomas' UK Adult Twin Registry (Twins UK). Results: Minor allele frequencies were as follows: rs4969169=0.067, rs12953258=0.097 and rs8064821=0.101. Individual SOCS3 SNPs were not associated with general or central obesity, or with two indices of insulin sensitivity (homeostasis model assessment and insulin sensitivity measure). Conclusions/ interpretation: The results do not indicate that any of the three SNPs studied are associated with obesity, insulin measures or lipid measures.

Original languageEnglish (US)
Pages (from-to)306-310
Number of pages5
JournalDiabetologia
Volume49
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

Single Nucleotide Polymorphism
Insulin Resistance
Body Weight
Lipids
Gene Frequency
Obesity
Abdominal Obesity
Linkage Disequilibrium
Leptin
Registries
Signal Transduction
Homeostasis
Insulin
Cytokines
Serum
Population

Keywords

  • Insulin resistance
  • Insulin sensitivity
  • Obesity
  • Weight regulation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. / Jamshidi, Y.; Snieder, H.; Wang, Xiaoling; Spector, T. D.; Carter, N. D.; O'Dell, S. D.

In: Diabetologia, Vol. 49, No. 2, 01.02.2006, p. 306-310.

Research output: Contribution to journalArticle

Jamshidi, Y. ; Snieder, H. ; Wang, Xiaoling ; Spector, T. D. ; Carter, N. D. ; O'Dell, S. D. / Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. In: Diabetologia. 2006 ; Vol. 49, No. 2. pp. 306-310.
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