Common STAT3 variants are not associated with obesity or insulin resistance in female twins

Yalda Jamshidi, Theodosios Kyriakou, Sakina B. Gooljar, Laura J. Collins, Carl A. Lane, Harold Snieder, Xiaoling Wang, Tim D. Spector, Sandra D. O'Dell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In animal models, STAT3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. We hypothesized that variation in the STAT3 gene may be associated with body fat and/or insulin resistance in the general population. Five tagging SNPs spanning the STAT3 gene, rs8074524, rs2293152, rs2306580, rs6503695, and rs7211777 were genotyped in 2776 white female twins (mean age, 47.4 ± 12.5 yrs) from the St Thomas' United Kingdom Adult Twin Registry (Twins UK). Minor allele frequencies were as follows: rs8074524 (0.19), rs2293152 (0.37), rs2306580 (0.06), rs6503695 (0.35), and rs7211777 (0.34). The minor allele of rs2293152 was associated with higher homeostasis model assessment index of insulin resistance (p = 0.013) in the full cohort and confirmed in sib-transmission/disequilibrium test (TDT): (p = 0.015; n = 60). However, there were no associations with fasting serum insulin or glucose or with obesity variables. Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study.

Original languageEnglish (US)
Pages (from-to)1634-1639
Number of pages6
JournalObesity
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2007

Fingerprint

Insulin Resistance
Obesity
Single Nucleotide Polymorphism
Homeostasis
Animal Models
Insulin
Glucose
Ideal Body Weight
Gene Frequency
Genes
Hypothalamus
Registries
Adipose Tissue
Fasting
Alleles
Liver
Serum
Population
United Kingdom

Keywords

  • Fat distribution
  • Genetic susceptibility
  • Insulin resistance
  • Signal transduction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Jamshidi, Y., Kyriakou, T., Gooljar, S. B., Collins, L. J., Lane, C. A., Snieder, H., ... O'Dell, S. D. (2007). Common STAT3 variants are not associated with obesity or insulin resistance in female twins. Obesity, 15(7), 1634-1639. https://doi.org/10.1038/oby.2007.194

Common STAT3 variants are not associated with obesity or insulin resistance in female twins. / Jamshidi, Yalda; Kyriakou, Theodosios; Gooljar, Sakina B.; Collins, Laura J.; Lane, Carl A.; Snieder, Harold; Wang, Xiaoling; Spector, Tim D.; O'Dell, Sandra D.

In: Obesity, Vol. 15, No. 7, 01.07.2007, p. 1634-1639.

Research output: Contribution to journalArticle

Jamshidi, Y, Kyriakou, T, Gooljar, SB, Collins, LJ, Lane, CA, Snieder, H, Wang, X, Spector, TD & O'Dell, SD 2007, 'Common STAT3 variants are not associated with obesity or insulin resistance in female twins', Obesity, vol. 15, no. 7, pp. 1634-1639. https://doi.org/10.1038/oby.2007.194
Jamshidi Y, Kyriakou T, Gooljar SB, Collins LJ, Lane CA, Snieder H et al. Common STAT3 variants are not associated with obesity or insulin resistance in female twins. Obesity. 2007 Jul 1;15(7):1634-1639. https://doi.org/10.1038/oby.2007.194
Jamshidi, Yalda ; Kyriakou, Theodosios ; Gooljar, Sakina B. ; Collins, Laura J. ; Lane, Carl A. ; Snieder, Harold ; Wang, Xiaoling ; Spector, Tim D. ; O'Dell, Sandra D. / Common STAT3 variants are not associated with obesity or insulin resistance in female twins. In: Obesity. 2007 ; Vol. 15, No. 7. pp. 1634-1639.
@article{e4786bcfc2a04b509852a586c283e06a,
title = "Common STAT3 variants are not associated with obesity or insulin resistance in female twins",
abstract = "In animal models, STAT3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. We hypothesized that variation in the STAT3 gene may be associated with body fat and/or insulin resistance in the general population. Five tagging SNPs spanning the STAT3 gene, rs8074524, rs2293152, rs2306580, rs6503695, and rs7211777 were genotyped in 2776 white female twins (mean age, 47.4 ± 12.5 yrs) from the St Thomas' United Kingdom Adult Twin Registry (Twins UK). Minor allele frequencies were as follows: rs8074524 (0.19), rs2293152 (0.37), rs2306580 (0.06), rs6503695 (0.35), and rs7211777 (0.34). The minor allele of rs2293152 was associated with higher homeostasis model assessment index of insulin resistance (p = 0.013) in the full cohort and confirmed in sib-transmission/disequilibrium test (TDT): (p = 0.015; n = 60). However, there were no associations with fasting serum insulin or glucose or with obesity variables. Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study.",
keywords = "Fat distribution, Genetic susceptibility, Insulin resistance, Signal transduction",
author = "Yalda Jamshidi and Theodosios Kyriakou and Gooljar, {Sakina B.} and Collins, {Laura J.} and Lane, {Carl A.} and Harold Snieder and Xiaoling Wang and Spector, {Tim D.} and O'Dell, {Sandra D.}",
year = "2007",
month = "7",
day = "1",
doi = "10.1038/oby.2007.194",
language = "English (US)",
volume = "15",
pages = "1634--1639",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Common STAT3 variants are not associated with obesity or insulin resistance in female twins

AU - Jamshidi, Yalda

AU - Kyriakou, Theodosios

AU - Gooljar, Sakina B.

AU - Collins, Laura J.

AU - Lane, Carl A.

AU - Snieder, Harold

AU - Wang, Xiaoling

AU - Spector, Tim D.

AU - O'Dell, Sandra D.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - In animal models, STAT3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. We hypothesized that variation in the STAT3 gene may be associated with body fat and/or insulin resistance in the general population. Five tagging SNPs spanning the STAT3 gene, rs8074524, rs2293152, rs2306580, rs6503695, and rs7211777 were genotyped in 2776 white female twins (mean age, 47.4 ± 12.5 yrs) from the St Thomas' United Kingdom Adult Twin Registry (Twins UK). Minor allele frequencies were as follows: rs8074524 (0.19), rs2293152 (0.37), rs2306580 (0.06), rs6503695 (0.35), and rs7211777 (0.34). The minor allele of rs2293152 was associated with higher homeostasis model assessment index of insulin resistance (p = 0.013) in the full cohort and confirmed in sib-transmission/disequilibrium test (TDT): (p = 0.015; n = 60). However, there were no associations with fasting serum insulin or glucose or with obesity variables. Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study.

AB - In animal models, STAT3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. We hypothesized that variation in the STAT3 gene may be associated with body fat and/or insulin resistance in the general population. Five tagging SNPs spanning the STAT3 gene, rs8074524, rs2293152, rs2306580, rs6503695, and rs7211777 were genotyped in 2776 white female twins (mean age, 47.4 ± 12.5 yrs) from the St Thomas' United Kingdom Adult Twin Registry (Twins UK). Minor allele frequencies were as follows: rs8074524 (0.19), rs2293152 (0.37), rs2306580 (0.06), rs6503695 (0.35), and rs7211777 (0.34). The minor allele of rs2293152 was associated with higher homeostasis model assessment index of insulin resistance (p = 0.013) in the full cohort and confirmed in sib-transmission/disequilibrium test (TDT): (p = 0.015; n = 60). However, there were no associations with fasting serum insulin or glucose or with obesity variables. Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study.

KW - Fat distribution

KW - Genetic susceptibility

KW - Insulin resistance

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=34547934976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547934976&partnerID=8YFLogxK

U2 - 10.1038/oby.2007.194

DO - 10.1038/oby.2007.194

M3 - Article

C2 - 17636079

AN - SCOPUS:34547934976

VL - 15

SP - 1634

EP - 1639

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 7

ER -