Common STAT3 variants are not associated with obesity or insulin resistance in female twins

Yalda Jamshidi, Theodosios Kyriakou, Sakina B. Gooljar, Laura J. Collins, Carl A. Lane, Harold Snieder, Xiaoling Wang, Tim D. Spector, Sandra D. O'Dell

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In animal models, STAT3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. We hypothesized that variation in the STAT3 gene may be associated with body fat and/or insulin resistance in the general population. Five tagging SNPs spanning the STAT3 gene, rs8074524, rs2293152, rs2306580, rs6503695, and rs7211777 were genotyped in 2776 white female twins (mean age, 47.4 ± 12.5 yrs) from the St Thomas' United Kingdom Adult Twin Registry (Twins UK). Minor allele frequencies were as follows: rs8074524 (0.19), rs2293152 (0.37), rs2306580 (0.06), rs6503695 (0.35), and rs7211777 (0.34). The minor allele of rs2293152 was associated with higher homeostasis model assessment index of insulin resistance (p = 0.013) in the full cohort and confirmed in sib-transmission/disequilibrium test (TDT): (p = 0.015; n = 60). However, there were no associations with fasting serum insulin or glucose or with obesity variables. Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study.

Original languageEnglish (US)
Pages (from-to)1634-1639
Number of pages6
JournalObesity
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2007

Keywords

  • Fat distribution
  • Genetic susceptibility
  • Insulin resistance
  • Signal transduction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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    Jamshidi, Y., Kyriakou, T., Gooljar, S. B., Collins, L. J., Lane, C. A., Snieder, H., Wang, X., Spector, T. D., & O'Dell, S. D. (2007). Common STAT3 variants are not associated with obesity or insulin resistance in female twins. Obesity, 15(7), 1634-1639. https://doi.org/10.1038/oby.2007.194