Communication-microelectrode detection of cholesterol efflux from the human buccel mucosa

Xiaochun Yu, Thomas J. Kelley, Hillel J. Chiel, James D. Burgess

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

It has previously demonstrated that cholesterol efflux from the cell plasma membrane is increased in a mouse model of cystic fibrosis (CF) compared to a wild-type control. A noninvasive means of characterizing plasma membrane cholesterol efflux at the surface of airway tissue of CF patients is needed to extend the trends found in animal models of CF to the human disease state. Microelectrode-induced cholesterol efflux from the plasma membrane of cells at the surface of tissue is proposed as a strategy to demonstrate increased cholesterol efflux for CF in human subjects. Data demonstrating detection of cholesterol efflux from the human buccal mucosa is reported as proof-of-concept for an in vivo diagnostic assay.

Original languageEnglish (US)
Pages (from-to)B453-B455
JournalJournal of the Electrochemical Society
Volume163
Issue number8
DOIs
StatePublished - Jan 1 2016

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Renewable Energy, Sustainability and the Environment
  • Surfaces, Coatings and Films
  • Electrochemistry
  • Materials Chemistry

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