Comparative genomic hybridization and its application to Wilms' tumorigenesis

M. E. Getman, B. T.W. Houseal, G. A. Miller, P. E. Grundy, J. K. Cowell, G. M. Landes

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Eighty sporadic Wilms' tumor samples were analyzed by comparative genomic hybridization (CGH) to identify chromosomal regions involved in the etiology of the disease. Twenty percent of the samples showed chromosomal gains or losses. The majority of chromosomal gains and losses were similar to those identified through molecular and cytogenetic studies. Gains were observed on chromosomes 1q, 7q, 8, and 12, whereas losses were found on chromosomes 1p, 4p, 4q, 7p, 16q, 18q, 21q, and 22q. Other genetic aberrations identified in this study included deletions of chromosomes 5p and 15q, as well as gains of discrete loci on chromosomes 3p and 3q. These latter regions have not been previously implicated in Wilms' tumorigenesis and may contain novel genes relevant to the development and/or progression of this disease.

Original languageEnglish (US)
Pages (from-to)284-290
Number of pages7
JournalCytogenetics and Cell Genetics
Volume82
Issue number3-4
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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